Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
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Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthasesIdentification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabHCloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strainDiscovery of FabH/FabF inhibitors from natural products.1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanismCrystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase IIIX-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by ThiolactomycinStructural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium TuberculosisTHPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteriaUsing modern tools to probe the structure-function relationship of fatty acid synthasesStructural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestisInactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatisIn vitro activity of a novel antimycobacterial compound, N-octanesulfonylacetamide, and its effects on lipid and mycolic acid synthesisThiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteriaIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growthBiochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase IIACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteriaPurification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasBDeletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent miceGalactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferaseMycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosisSignature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosisPleiotropic effect of AccD5 and AccE5 depletion in acyl-coenzyme A carboxylase activity and in lipid biosynthesis in mycobacteriaIdentification of KasA as the cellular target of an anti-tubercular scaffoldGlycosidase inhibitors: a patent review (2008-2013).Transposon-5 mutagenesis transforms Corynebacterium matruchotii to synthesize novel hybrid fatty acids that functionally replace corynomycolic acidSynthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitorsLoss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones.Response of Bacillus subtilis to cerulenin and acquisition of resistance.Novel tetracyclic structures from the synthesis of thiolactone-isatin hybridsA missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length.Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylationStructure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.Depletion of antibiotic targets has widely varying effects on growth
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P2860
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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type
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Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
@ast
Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
@en
Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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Thiolactomycin and related ana ...... in Mycobacterium tuberculosis
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A R Baulard
C Morehouse
D E Minnikin
J D Douglas
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10.1074/JBC.M000569200
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P577
2000-06-02T00:00:00Z