Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors - Wikidata - thesis-toulmin - TriplyDB

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors

Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors

http://www.wikidata.org/entity/Q28475319

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NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships Deciphering the role of hedgehog signaling in pancreatic cancer Targeting the Hedgehog Pathway in Pediatric Medulloblastoma Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy Epidermal growth factor signaling in transformed cells ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity ERK as a model for systems biology of enzyme kinetics in cells.Combining docking site and phosphosite predictions to find new substrates: identification of smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate Predicting dynamic signaling network response under unseen perturbations.Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1 Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells Cooperative Hedgehog-EGFR signaling The human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2 Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal.Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways.Kinase-Associated Phosphoisoform Assay: a novel candidate-based method to detect specific kinase-substrate phosphorylation interactions in vivo.Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions.FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway.Acute myeloid leukemia - strategies and challenges for targeting oncogenic Hedgehog/GLI signaling Uncovering new aspects of protein interactions through analysis of specificity landscapes in peptide recognition domains.Canonical and non-canonical Hedgehog signalling and the control of metabolism.Protein-protein interactions in plant mitogen-activated protein kinase cascades.Inhibition of hedgehog signalling attenuates UVB-induced skin photoageing.Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).A novel dual signaling axis for NSP 5a3a induced apoptosis in head and neck carcinoma.An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma.Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases.Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells.Characterisation of de novo MAPK10/JNK3 truncation mutations associated with cognitive disorders in two unrelated patients.Sonic Hedgehog Signaling in Thyroid Cancer.Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

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Computational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factors

http://www.wikidata.org/entity/Q28475319

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Computational prediction and e ...... ding Gli transcription factors

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Computational prediction and e ...... ding Gli transcription factors

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Computational prediction and e ...... ding Gli transcription factors

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type

label

Computational prediction and e ...... ding Gli transcription factors

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Computational prediction and e ...... ding Gli transcription factors

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Computational prediction and e ...... ding Gli transcription factors

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Computational prediction and e ...... ding Gli transcription factors

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Computational prediction and e ...... ding Gli transcription factors

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Computational prediction and e ...... ding Gli transcription factors

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JOURNAL.PCBI.1000908

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PLOS Computational Biology

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Computational prediction and e ...... ding Gli transcription factors

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David T Ho

http://www.w3.org/2001/XMLSchema#string

Elizabeth A Gordon

http://www.w3.org/2001/XMLSchema#string

Jeffrey S Rogers

http://www.w3.org/2001/XMLSchema#string

Lan Huang

http://www.w3.org/2001/XMLSchema#string

Pierre Baldi

http://www.w3.org/2001/XMLSchema#string

Robyn M Kaake

http://www.w3.org/2001/XMLSchema#string

Ryan W Benz

http://www.w3.org/2001/XMLSchema#string

Thomas C Whisenant

http://www.w3.org/2001/XMLSchema#string

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The JIP group of mitogen-activated protein kinase scaffold proteins

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif

Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity

The protein kinase complement of the human genome

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways

A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria

An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase

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e1000908

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scholarly article

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2286728

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10.1371/JOURNAL.PCBI.1000908

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2010-08-26T00:00:00Z

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20865152

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