PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90
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Role of Heat-Shock Proteins in Cellular Function and in the Biology of FungipH signaling in human fungal pathogens: a new target for antifungal strategiesSynergistic combinations of antifungals and anti-virulence agents to fight against Candida albicansHsp90 governs dispersion and drug resistance of fungal biofilmsCalcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicansMapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitryThe Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistanceGlobal analysis of the evolution and mechanism of echinocandin resistance in Candida glabrataGenetic and genomic architecture of the evolution of resistance to antifungal drug combinationsHsp21 potentiates antifungal drug tolerance in Candida albicansFitness trade-offs restrict the evolution of resistance to amphotericin BFunctional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular StatesMapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular StressMetal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and MorphogenesisSelective BET bromodomain inhibition as an antifungal therapeutic strategyHighly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans.Mechanisms of Candida albicans trafficking to the brain.Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints.Synergistic Activity of Econazole-Nitrate and Chelerythrine against Clinical Isolates of Candida albicansRegulatory circuitry governing fungal development, drug resistance, and disease.Elucidating drug resistance in human fungal pathogens.Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway.Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.G1/S transcription factor orthologues Swi4p and Swi6p are important but not essential for cell proliferation and influence hyphal development in the fungal pathogen Candida albicans.Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal moleculesSur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans.Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo.The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans.The Aspergillus fumigatus pkcA G579R Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model.Targeting the oxidative stress response system of fungi with redox-potent chemosensitizing agents.Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans.Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicansSignaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal PathogensThe non-Geldanamycin Hsp90 inhibitors enhanced the antifungal activity of fluconazole.Molecular Characterization of Gβ-Like Protein CpcB Involved in Antifungal Drug Susceptibility and Virulence in A. fumigatusTacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosisSurface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans.Candida albicans pathogenicity mechanisms.
P2860
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P2860
PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@ast
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@en
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@nl
type
label
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@ast
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@en
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@nl
prefLabel
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@ast
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@en
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@nl
P2093
P2860
P3181
P1433
P1476
PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90
@en
P2093
A A Leslie Gunatilaka
Aimee K Zaas
Cathy Collins
Marisol Betancourt-Quiroz
Shantelle L LaFayette
Wiley A Schell
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1001069
P407
P577
2010-08-26T00:00:00Z