Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis
about
Chapter 7: PharmacogenomicsDelineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint ApproachTranslational bioinformatics: linking the molecular world to the clinical worldPREDICT: a method for inferring novel drug indications with application to personalized medicineNew target prediction and visualization tools incorporating open source molecular fingerprints for TB Mobile 2.0Calculating an optimal box size for ligand docking and virtual screening against experimental and predicted binding pocketsRaloxifene attenuates Pseudomonas aeruginosa pyocyanin production and virulenceA machine learning-based method to improve docking scoring functions and its application to drug repurposingBinding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurementsDrug off-target effects predicted using structural analysis in the context of a metabolic network modelThe Mycobacterium tuberculosis drugome and its polypharmacological implicationsA computational approach to finding novel targets for existing drugsDrug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavirAssessing drug target association using semantic linked dataA global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targetsDrug repositioning by kernel-based integration of molecular structure, molecular activity, and phenotype dataOpen-source approaches for the repurposing of existing or failed candidate drugs: learning from and applying the lessons across diseasesMemantine, an antagonist of the NMDA glutamate receptor, affects cell proliferation, differentiation and the intracellular cycle and induces apoptosis in Trypanosoma cruziNeighborhood Regularized Logistic Matrix Factorization for Drug-Target Interaction PredictionLarge-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug RepurposingKnowledge Discovery from Biomedical Ontologies in Cross DomainsAchievements and challenges in structural bioinformatics and computational biophysicsA miRNA-driven inference model to construct potential drug-disease associations for drug repositioningImproved genome-scale multi-target virtual screening via a novel collaborative filtering approach to cold-start problem.Harnessing Big Data for Systems PharmacologyProBiS-ligands: a web server for prediction of ligands by examination of protein binding sites.SMAP-WS: a parallel web service for structural proteome-wide ligand-binding site comparison.Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.Investigating the Importance of the Pocket-estimation Method in Pocket-based Approaches: An Illustration Using Pocket-ligand Classification.Drug discovery and the use of computational approaches for infectious diseases.Space-related pharma-motifs for fast search of protein binding motifs and polypharmacological targets.Computational drug repositioning: from data to therapeutics.IDEA: Integrated Drug Expression Analysis-Integration of Gene Expression and Clinical Data for the Identification of Therapeutic Candidates.Providing data science support for systems pharmacology and its implications to drug discoveryToward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines.Towards building a disease-phenotype knowledge base: extracting disease-manifestation relationship from literature.Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration.Molecular mechanisms involved in the side effects of fatty acid amide hydrolase inhibitors: a structural phenomics approach to proteome-wide cellular off-target deconvolution and disease association.Discovery and preclinical validation of drug indications using compendia of public gene expression data.PESDserv: a server for high-throughput comparison of protein binding site surfaces.
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P2860
Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Drug discovery using chemical ...... ly drug resistant tuberculosis
@ast
Drug discovery using chemical ...... ly drug resistant tuberculosis
@en
Drug discovery using chemical ...... ly drug resistant tuberculosis
@nl
type
label
Drug discovery using chemical ...... ly drug resistant tuberculosis
@ast
Drug discovery using chemical ...... ly drug resistant tuberculosis
@en
Drug discovery using chemical ...... ly drug resistant tuberculosis
@nl
prefLabel
Drug discovery using chemical ...... ly drug resistant tuberculosis
@ast
Drug discovery using chemical ...... ly drug resistant tuberculosis
@en
Drug discovery using chemical ...... ly drug resistant tuberculosis
@nl
P2093
P2860
P50
P921
P3181
P1476
Drug discovery using chemical ...... ly drug resistant tuberculosis
@en
P2093
Nancy Buchmeier
Sarah L Kinnings
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1000423
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P577
2009-07-01T00:00:00Z