Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha
about
A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1α pathwayExpression of MDR1, HIF-1α and MRP1 in sacral chordoma and chordoma cell line CM-319Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survivalDegradation of mutant p53H175 protein by Zn(II) through autophagy.Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivoHigh glucose dephosphorylates serine 46 and inhibits p53 apoptotic activityUnfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancerHIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.Reciprocal influence of the p53 and the hypoxic pathwaysGenome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation.The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cellsZn(II)-curc targets p53 in thyroid cancer cellsTargeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapyRole of miR-27a, miR-181a and miR-20b in gastric cancer hypoxia-induced chemoresistance.Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells.Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses.A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.HIPK2 modulates p53 activity towards pro-apoptotic transcription.ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose.Hyperglycemia triggers HIPK2 protein degradation.Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.Zinc and zinc-containing biomolecules in childhood brain tumors.HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.HIPK2 expression in progression of cutaneous epithelial neoplasm.HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma.[Research progress and application of the homeodomain-interacting protein kinase-2].
P2860
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P2860
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@ast
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@en
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@nl
type
label
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@ast
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@en
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@nl
prefLabel
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@ast
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@en
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@nl
P2093
P2860
P50
P3181
P1433
P1476
Targeting hypoxia in cancer ce ...... ity and suppressing HIF-1alpha
@en
P2093
David Givol
Gideon Rechavi
P2860
P3181
P356
10.1371/JOURNAL.PONE.0006819
P407
P577
2009-08-28T00:00:00Z