A role for both conformational selection and induced fit in ligand binding by the LAO protein
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Conformational selection in protein binding and functionDynamic Modelling Reveals 'Hotspots' on the Pathway to Enzyme-Substrate Complex Formation.A Jump-from-Cavity Pyrophosphate Ion Release Assisted by a Key Lysine Residue in T7 RNA Polymerase Transcription ElongationBridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residueAn extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signalMinimum free energy path of ligand-induced transition in adenylate kinaseLigand concentration regulates the pathways of coupled protein folding and binding.The impact of small molecule binding on the energy landscape of the intrinsically disordered protein C-mycThe role of flexibility and conformational selection in the binding promiscuity of PDZ domainsUtilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugsQuantitatively characterizing the ligand binding mechanisms of choline binding protein using Markov state model analysisQuantitative comparison of alternative methods for coarse-graining biological networksMolecular dynamics simulations reveal that apo-HisJ can sample a closed conformation.Type 1 and Type 2 scenarios in hydrogen exchange mass spectrometry studies on protein-ligand complexes.Millisecond dynamics of RNA polymerase II translocation at atomic resolutionDynamically-driven enhancement of the catalytic machinery of the SARS 3C-like protease by the S284-T285-I286/A mutations on the extra domain.Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fitQuantifying the Sources of Kinetic Frustration in Folding Simulations of Small Proteins.Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.Exploration of multi-state conformational dynamics and underlying global functional landscape of maltose binding protein.Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites.A two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase.Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coliMarkov State Models Reveal a Two-Step Mechanism of miRNA Loading into the Human Argonaute Protein: Selective Binding followed by Structural Re-arrangement.Bioinformatics and variability in drug response: a protein structural perspective.Conformational Dynamics of apo-GlnBP Revealed by Experimental and Computational Analysis.Conformational selection and induced fit for RNA polymerase and RNA/DNA hybrid backtracked recognition.Migration of small ligands in globins: Xe diffusion in truncated hemoglobin N.The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis.Rational prediction with molecular dynamics for hit identificationComputational models of protein kinematics and dynamics: beyond simulation.Conformational Heterogeneity in the Michaelis Complex of Lactate Dehydrogenase: An Analysis of Vibrational Spectroscopy Using Markov and Hidden Markov ModelsMultiensemble Markov models of molecular thermodynamics and kinetics.Elucidation of the Dynamics of Transcription Elongation by RNA Polymerase II using Kinetic Network ModelsMultiscale modeling of macromolecular biosystems.Induced fit or conformational selection? The role of the semi-closed state in the maltose binding proteinSimple, yet powerful methodologies for conformational sampling of proteins.Flexible receptor docking for drug discovery.Elucidation of the conformational dynamics of multi-body systems by construction of Markov state models.An integrated perspective on RNA aptamer ligand-recognition models: clearing muddy waters.
P2860
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P2860
A role for both conformational selection and induced fit in ligand binding by the LAO protein
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A role for both conformational ...... and binding by the LAO protein
@ast
A role for both conformational ...... and binding by the LAO protein
@en
A role for both conformational ...... and binding by the LAO protein
@nl
type
label
A role for both conformational ...... and binding by the LAO protein
@ast
A role for both conformational ...... and binding by the LAO protein
@en
A role for both conformational ...... and binding by the LAO protein
@nl
prefLabel
A role for both conformational ...... and binding by the LAO protein
@ast
A role for both conformational ...... and binding by the LAO protein
@en
A role for both conformational ...... and binding by the LAO protein
@nl
P2860
P3181
P1476
A role for both conformational ...... and binding by the LAO protein
@en
P2093
Alejandro Sosa-Peinado
Gregory R Bowman
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1002054
P407
P577
2011-05-01T00:00:00Z