Munc18c depletion selectively impairs the sustained phase of insulin release
about
Distinct initial SNARE configurations underlying the diversity of exocytosisSignaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cellsMunc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cellsDifferential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion.Exocytosis mechanisms underlying insulin release and glucose uptake: conserved roles for Munc18c and syntaxin 4Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivityDisruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function.The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulationPhosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic β-cellsMunc18c: a controversial regulator of peripheral insulin action.Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosisMunc18-1 and Munc18-2 proteins modulate beta-cell Ca2+ sensitivity and kinetics of insulin exocytosis differently.Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cellsGelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoformsDoc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivityMicroarray analysis of Xenopus endoderm expressing Ptf1a.Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscleSpecialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs.Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins.Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells.Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells.Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.Modes of exocytosis and electrogenesis underlying canine biphasic insulin secretion.Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion.Insulin/phosphoinositide 3-kinase pathway accelerates the glucose-induced first-phase insulin secretion through TrpV2 recruitment in pancreatic β-cells.Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells.Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins.Munc18c depletion attenuates caerulein hyperstimulation induced pancreatitis.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Recent new insights into the role of SNARE and associated proteins in insulin granule exocytosis.Munc18a clusters SNARE-bearing liposomes prior to trans-SNARE zippering.
P2860
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P2860
Munc18c depletion selectively impairs the sustained phase of insulin release
description
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Mai 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/05/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/05/01)
@nl
наукова стаття, опублікована в травні 2009
@uk
مقالة علمية (نشرت في مايو 2009)
@ar
name
Munc18c depletion selectively impairs the sustained phase of insulin release
@ast
Munc18c depletion selectively impairs the sustained phase of insulin release
@en
Munc18c depletion selectively impairs the sustained phase of insulin release
@nl
type
label
Munc18c depletion selectively impairs the sustained phase of insulin release
@ast
Munc18c depletion selectively impairs the sustained phase of insulin release
@en
Munc18c depletion selectively impairs the sustained phase of insulin release
@nl
prefLabel
Munc18c depletion selectively impairs the sustained phase of insulin release
@ast
Munc18c depletion selectively impairs the sustained phase of insulin release
@en
Munc18c depletion selectively impairs the sustained phase of insulin release
@nl
P2860
P921
P356
P1433
P1476
Munc18c depletion selectively impairs the sustained phase of insulin release
@en
P2093
Debbie C. Thurmond
P2860
P304
P356
10.2337/DB08-1059
P407
P577
2009-05-01T00:00:00Z