Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors
about
Mammalian nicotinic acetylcholine receptors: from structure to functionEarly Signs of Pathological Cognitive Aging in Mice Lacking High-Affinity Nicotinic Receptors.NMR structure of the transmembrane domain of the n-acetylcholine receptor β2 subunitTargeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.The chaperone protein 14-3-3eta interacts with the nicotinic acetylcholine receptor alpha 4 subunit. Evidence for a dynamic role in subunit stabilizationRequirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging.Requirement of the nicotinic acetylcholine receptor beta 2 subunit for the anatomical and functional development of the visual systemPoint mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety.Executive and social behaviors under nicotinic receptor regulationAge-related hearing loss: GABA, nicotinic acetylcholine and NMDA receptor expression changes in spiral ganglion neurons of the mouse.Acute stress in adulthood impoverishes social choices and triggers aggressiveness in preclinical models.Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutationsMuscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophreniaOld mice lacking high-affinity nicotine receptors resist acoustic trauma.Why do hair cells and spiral ganglion neurons in the cochlea die during aging?Age-related loss of spiral ganglion neuronsThe role of glucocorticoids for spiral ganglion neuron survival.Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice.Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction.Acetylcholine receptors and myasthenia.Mouse mutants for the nicotinic acetylcholine receptor ß2 subunit display changes in cell adhesion and neurodegeneration response genes.Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.Pharmacokinetics and safety profile of ispronicline (TC-1734), a new brain nicotinic receptor partial agonist, in young healthy male volunteers.II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus.The effects of aging vs. α7 nAChR subunit deficiency on the mouse brain transcriptome: aging beats the deficiency.Nicotinic acetylcholine receptors as targets for antidepressants.Inhibition of human alpha 7 nicotinic acetylcholine receptors by open channel blockers of N-methyl-D-aspartate receptors.Lynx1 supports neuronal health in the mouse dorsal striatum during aging: an ultrastructural investigation.Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea.Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits.Emerging concepts: novel integration of in vivo approaches to localize the function of nicotinic receptors.Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity.Neuronal nicotinic receptors as novel targets for inflammation and neuroprotection: mechanistic considerations and clinical relevance.Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings.Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotypeImpact of ageing on postsynaptic neuronal nicotinic neurotransmission in auditory thalamus.A threshold model for opposing actions of acetylcholine on reward behavior: Molecular mechanisms and implications for treatment of substance abuse disorders.Neuronal survival in the brain: neuron type-specific mechanisms.Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitryThe Ferrier Lecture 1998. The molecular biology of consciousness investigated with genetically modified mice.
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P2860
Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors
description
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
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im März 1999 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 1999/03/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/03/01)
@nl
наукова стаття, опублікована в березні 1999
@uk
مقالة علمية (نشرت في مارس 1999)
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name
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@ast
Increased neurodegeneration du ...... gh-affinity nicotine receptors
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Increased neurodegeneration du ...... gh-affinity nicotine receptors
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type
label
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@ast
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@en
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@nl
prefLabel
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@ast
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@en
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@nl
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P1476
Increased neurodegeneration du ...... gh-affinity nicotine receptors
@en
P2093
J. P. Changeux
M. R. Picciotto
R. Ferrari
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P304
P3181
P356
10.1093/EMBOJ/18.5.1235
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P50
P577
1999-03-01T00:00:00Z