Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
about
Functional characterization of a human aquaporin 0 mutation that leads to a congenital dominant lens cataract.Intact AQP0 performs cell-to-cell adhesionFunctional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesionNine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive errorAquaporin-1-facilitated keratocyte migration in cell culture and in vivo corneal wound healing modelsFunctional expression of aquaporins in embryonic, postnatal, and adult mouse lensesTransgenic overexpression of connexin50 induces cataracts.MALDI imaging mass spectrometry of integral membrane proteins from ocular lens and retinal tissuePKC putative phosphorylation site Ser235 is required for MIP/AQP0 translocation to the plasma membrane.Dynamic control of slow water transport by aquaporin 0: implications for hydration and junction stability in the eye lensTransgenic expression of AQP1 in the fiber cells of AQP0 knockout mouse: effects on lens transparency.Physiological role of aquaporin 5 in salivary glands.Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.A novel terminal web-like structure in cortical lens fibers: architecture and functional assessment.MIP/Aquaporin 0 represents a direct transcriptional target of PITX3 in the developing lens.Cat-Map: putting cataract on the mapThe Arg233Lys AQP0 mutation disturbs aquaporin0-calmodulin interaction causing polymorphic congenital cataract.Development of a macromolecular diffusion pathway in the lens.A novel mutation in MIP associated with congenital nuclear cataract in a Chinese family.A 5-bp insertion in Mip causes recessive congenital cataract in KFRS4/Kyo ratsTwo distinct aquaporin 0s required for development and transparency of the zebrafish lens.The cellular and molecular mechanisms of vertebrate lens development.Thermal stress induced aggregation of aquaporin 0 (AQP0) and protection by α-crystallin via its chaperone function.Unique and analogous functions of aquaporin 0 for fiber cell architecture and ocular lens transparency.A novel nonsense mutation in the MIP gene linked to congenital posterior polar cataracts in a Chinese family.Further analysis of the lens phenotype in Lim2-deficient mice.Identification and Functional Analysis of a Novel MIP Gene Mutation Associated with Congenital Cataract in a Chinese Family.The pH sensitivity of Aqp0 channels in tetraploid and diploid teleosts.MALDI Imaging Mass Spectrometry Spatially Maps Age-Related Deamidation and Truncation of Human Lens Aquaporin-0.Functions of aquaporins in the eyeAuto-Adhesion Potential of Extraocular Aqp0 during Teleost Development.Aquaporins in the eye: expression, function, and roles in ocular diseaseLens gap junctions in growth, differentiation, and homeostasis.Presbyopia: the first stage of nuclear cataract?Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish.An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract.Phosphorylation determines the calmodulin-mediated Ca2+ response and water permeability of AQP0The water permeability of lens aquaporin-0 depends on its lipid bilayer environment.Differentiation-dependent modification and subcellular distribution of aquaporin-0 suggests multiple functional roles in the rat lens.A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family.
P2860
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P2860
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
description
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Dezember 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/12/21)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/12/21)
@nl
наукова стаття, опублікована в грудні 2001
@uk
مقالة علمية (نشرت في 21-12-2001)
@ar
name
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@ast
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@en
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@nl
type
label
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@ast
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@en
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@nl
prefLabel
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@ast
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@en
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@nl
P2093
P3181
P1476
Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice
@en
P2093
B. Zambrowicz
D. Donoviel
G. Friedrich
K. Al-Ghoul
K. Varadaraj
R. Mathias
S. Bassnett
S. Lilleberg
P304
P3181
P356
10.1152/PHYSIOLGENOMICS.00078.2001
P577
2001-12-21T00:00:00Z