about
Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genesCD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signalsInhibition of the B cell by CD22: a requirement for LynSustained activation of Lyn tyrosine kinase in vivo leads to autoimmunityInterference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tailSiglecs in the immune systemSpontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted miceSiglecs as sensors of self in innate and adaptive immune responsesSiglecs and immune regulationCD22 and Siglec-G in B cell function and toleranceRethinking mechanisms of autoimmune pathogenesisIntravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium fluxCD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1CD22: an inhibitory enigmaGenetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esteraseAnalysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signalingThe motheaten mutation rescues B cell signaling and development in CD45-deficient miceTargeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune responseCarabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunitySialic acid binding domains of CD22 are required for negative regulation of B cell receptor signalingCloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells.Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells.Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activationAugmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse lineDecoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivoApotosis of mature B cells.Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.Mice deficient in APOBEC2 and APOBEC3.Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity.B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals.Lessons from the NZM2410 model and related strains.Lessons from BXSB and related mouse models.
P2860
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P2860
description
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1996
@ast
im November 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/11/01)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/11/01)
@nl
наукова стаття, опублікована в листопаді 1996
@uk
name
Hyperresponsive B cells in CD22-deficient mice
@ast
Hyperresponsive B cells in CD22-deficient mice
@en
Hyperresponsive B cells in CD22-deficient mice
@nl
type
label
Hyperresponsive B cells in CD22-deficient mice
@ast
Hyperresponsive B cells in CD22-deficient mice
@en
Hyperresponsive B cells in CD22-deficient mice
@nl
prefLabel
Hyperresponsive B cells in CD22-deficient mice
@ast
Hyperresponsive B cells in CD22-deficient mice
@en
Hyperresponsive B cells in CD22-deficient mice
@nl
P2093
P3181
P1433
P1476
Hyperresponsive B cells in CD22-deficient mice
@en
P2093
G. T. Williams
M. S. Neuberger
S. L. Davies
T. L. O'Keefe
P304
P3181
P356
10.1126/SCIENCE.274.5288.798
P407
P577
1996-11-01T00:00:00Z