deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes
about
Dlx genes, p63, and ectodermal dysplasias.p63 regulates proliferation and differentiation of developmentally mature keratinocytesp53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafishInsulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.Cross-regulation between Notch and p63 in keratinocyte commitment to differentiationp63 is the molecular switch for initiation of an epithelial stratification programDifferential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null miceDysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytesNovel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approachTP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Transcription factor p63 regulates key genes and wound repair in human airway epithelial basal cellsTranscriptional control of epidermal specification and differentiation.RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability.ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2.C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells.Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healingPhospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure.Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation.DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiationATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damageDeltaNp63alpha confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulationA composite enhancer regulates p63 gene expression in epidermal morphogenesis and in keratinocyte differentiation by multiple mechanisms.Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.p63 regulates olfactory stem cell self-renewal and differentiation.p63 induces key target genes required for epidermal morphogenesis.The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancersΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion.Transcription factor p63 controls the reserve status but not the stemness of horizontal basal cells in the olfactory epithelium.UBE4B: a promising regulatory molecule in neuronal death and survival.Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineeringThe proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63Notch tumor suppressor functionΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesisA symphony of regulations centered on p63 to control development of ectoderm-derived structures.Dysregulated ΔNp63α negatively regulates the maspin promoter in keratinocytes via blocking endogenous p73 binding.Differential recognition of response elements determines target gene specificity for p53 and p63p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma.Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch.New p63 targets in keratinocytes identified by a genome-wide approach.Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63.
P2860
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P2860
deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes
description
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juni 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/06/05)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/06/05)
@nl
наукова стаття, опублікована в червні 2003
@uk
مقالة علمية (نشرت في 5-6-2003)
@ar
name
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@ast
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@en
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@nl
type
label
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@ast
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@en
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@nl
prefLabel
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@ast
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@en
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@nl
P2093
P2860
P356
P1433
P1476
deltaNp63alpha functions as bo ...... iation of murine keratinocytes
@en
P2093
Kathryn E. King
Lela A. Lee
Marian F. Young
Roshini M. Ponnamperuma
Takashi Tokino
Toshiharu Yamashita
Wendy C. Weinberg
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206536
P407
P577
2003-06-05T00:00:00Z
P6179
1006589554