Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
about
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionPeroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cellsSIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stressRole of ROS and RNS Sources in Physiological and Pathological ConditionsThe balance of powers: Redox regulation of fibrogenic pathways in kidney injuryElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsRedox implications in adipose tissue (dys)function--A new look at old acquaintancesForever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegenerationImpact of oxidative stress on exercising skeletal muscleSirtuin 1 and sirtuin 3: physiological modulators of metabolismRole of sirtuins in ischemia-reperfusion injuryRedox regulation of mitochondrial biogenesisTranscriptional integration of mitochondrial biogenesisOxidative stress and mitochondrial damage: importance in non-SOD1 ALSRole of mitochondria in nonalcoholic fatty liver diseaseFunction of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative diseaseSIRT3 in Cardiac Physiology and DiseaseRole of oxidative DNA damage in mitochondrial dysfunction and Huntington's disease pathogenesisOxidative stress and ROS metabolism via down-regulation of sirtuin 3 expression in Cmah-null mice affect hearing lossSIRT3 and cancer: tumor promoter or suppressor?Mitochondria and reactive oxygen species: physiology and pathophysiologyMetformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolismAge-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model.RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged miceNAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.MiR-146a regulates SOD2 expression in H2O2 stimulated PC12 cellsSIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells.Comparison of Sirtuin 3 Levels in ALS and Huntington's Disease-Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models.Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaningEmerging role of sirtuins on tumorigenesis: possible link between aging and cancerSirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2+ and mitochondrial biogenesis.SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.Mitochondrial uncouplers inhibit hepatic stellate cell activationAdiponectin alleviates genioglossal mitochondrial dysfunction in rats exposed to intermittent hypoxiaSkeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidationSirtuin catalysis and regulationThe role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma.SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilizationPathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning.
P2860
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P2860
Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis
description
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique PLoS ONE
@fr
artículu científicu espublizáu en 2010
@ast
im Juli 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/07/22)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/07/22)
@nl
наукова стаття, опублікована в липні 2010
@uk
name
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@ast
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@en
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@nl
type
label
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@ast
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@en
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@nl
prefLabel
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@ast
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@en
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@nl
P2093
P2860
P3181
P1433
P1476
Sirtuin 3, a new target of PGC ...... S and mitochondrial biogenesis
@en
P2093
Huabing Zhang
Xiaojun Liu
Xingxing Kong
Yongsheng Chang
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0011707
P407
P577
2010-07-22T00:00:00Z