Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton
about
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffoldsA meckelin-filamin A interaction mediates ciliogenesisTMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zoneCytoskeletal interactions at the nuclear envelope mediated by nesprinsThe role of RPGR in cilia formation and actin stabilityIdentification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotesMutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromesUnder Pressure: Mechanical Stress Management in the NucleusThe base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalizationThe role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesThe polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells.The centrosome is an actin-organizing centre.Nuclear migration events throughout developmentTMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndromeDynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genesA simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary ciliaATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerizationMeckelin 3 is necessary for photoreceptor outer segment development in rat Meckel syndromeEvolution: Tracing the origins of centrioles, cilia, and flagellaAn siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genesReduction of meckelin leads to general loss of cilia, ciliary microtubule misalignment and distorted cell surface organization.Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation.Evidence that TMEM67 causes polycystic kidney disease through activation of JNK/ERK-dependent pathways.Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells.Ofd1 controls dorso-ventral patterning and axoneme elongation during embryonic brain development.LINC complexes in health and disease.Soluble levels of cytosolic tubulin regulate ciliary length controlAccessorizing and anchoring the LINC complex for multifunctionality.Thiazolidinediones inhibit MDCK cyst growth through disrupting oriented cell division and apicobasal polarity.Ciliary diffusion barrier: the gatekeeper for the primary cilium compartment.The ciliary proteins Meckelin and Jouberin are required for retinoic acid-dependent neural differentiation of mouse embryonic stem cells.Bioinformatic analysis of ciliary transition zone proteins reveals insights into the evolution of ciliopathy networks.Stages of ciliogenesis and regulation of ciliary lengthNeural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans.Meckelin is necessary for photoreceptor intraciliary transport and outer segment morphogenesisKeeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function.Centrosome positioning in vertebrate development.
P2860
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P2860
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton
description
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im August 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/08/01)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/08/01)
@nl
наукова стаття, опублікована в серпні 2009
@uk
مقالة علمية (نشرت في أغسطس 2009)
@ar
name
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@ast
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@en
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@en-gb
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@nl
type
label
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@ast
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@en
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@en-gb
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@nl
prefLabel
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@ast
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@en
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@en-gb
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@nl
P2093
P2860
P921
P3181
P356
P1476
Nesprin-2 interacts with mecke ...... ling of the actin cytoskeleton
@en
P2093
Angelika A. Noegel
Colin A. Johnson
Helen R. Dawe
Katarzyna Szymanska
Keith Gull
Matthew Adams
P2860
P304
P3181
P356
10.1242/JCS.043794
P407
P577
2009-08-01T00:00:00Z