Glutathione synthesis is essential for mouse development but not for cell growth in culture
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Inborn errors in the metabolism of glutathioneUbiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathwayKnockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neuronsStructure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligaseManipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicityThe in vivo gene expression signature of oxidative stressInterplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathwayGlutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpAThe alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae.Oxidative stress, unfolded protein response, and apoptosis in developmental toxicityNrf1 is critical for redox balance and survival of liver cells during developmentEmbryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteinsGlutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levelsGlutamate Cysteine Ligase Modifier Subunit (Gclm) Null Mice Have Increased Ovarian Oxidative Stress and Accelerated Age-Related Ovarian FailureLack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in miceThioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signalingThe Roles of Glutathione Peroxidases during Embryo DevelopmentIn utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protectiveParadoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsNrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress responseSecisbp2 is essential for embryonic development and enhances selenoprotein expressionGlutathione protects cells against arsenite-induced toxicityA genetic investigation of the essential role of glutathione: mutations in the proline biosynthesis pathway are the only suppressors of glutathione auxotrophy in yeast.Identification of novel genes potentially involved in somatic embryogenesis in chicory (Cichorium intybus L.).Endogenous production of lipoic acid is essential for mouse developmentAn ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro.YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes.Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control.Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survivalPhysiological role of phospholipid hydroperoxide glutathione peroxidase in mammals.Control of angiogenesis dictated by picomolar superoxide levels.Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance.Transgenic mouse models for alcohol metabolism, toxicity, and cancer.Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunitsDietary methionine can sustain cytosolic redox homeostasis in the mouse liver.Unveiling the roles of the glutathione redox system in vivo by analyzing genetically modified mice.Mitochondrial energetics and therapeutics.Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice
P2860
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P2860
Glutathione synthesis is essential for mouse development but not for cell growth in culture
description
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2000
@ast
im Mai 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/05/09)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/05/09)
@nl
наукова стаття, опублікована в травні 2000
@uk
name
Glutathione synthesis is essen ...... not for cell growth in culture
@ast
Glutathione synthesis is essen ...... not for cell growth in culture
@en
Glutathione synthesis is essen ...... not for cell growth in culture
@nl
type
label
Glutathione synthesis is essen ...... not for cell growth in culture
@ast
Glutathione synthesis is essen ...... not for cell growth in culture
@en
Glutathione synthesis is essen ...... not for cell growth in culture
@nl
prefLabel
Glutathione synthesis is essen ...... not for cell growth in culture
@ast
Glutathione synthesis is essen ...... not for cell growth in culture
@en
Glutathione synthesis is essen ...... not for cell growth in culture
@nl
P2093
P2860
P356
P1476
Glutathione synthesis is essen ...... not for cell growth in culture
@en
P2093
C. M. Danney
D. J. Lukin
G. M. Habib
J. Osei-Frimpong
M. M. Matzuk
M. W. Lieberman
R. J. Barrios
S. V. Kala
P2860
P304
P356
10.1073/PNAS.97.10.5101
P407
P577
2000-05-09T00:00:00Z