Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
about
SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoRLiver x receptors in atherosclerosis and inflammationRole of nuclear receptor corepressor RIP140 in metabolic syndromePPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1TNF biology, pathogenic mechanisms and emerging therapeutic strategiesMetabolic reprogramming by class I and II histone deacetylasesMacrophages: gatekeepers of tissue integrityStructural basis for the assembly of the SMRT/NCoR core transcriptional repression machineryAnalysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-κB-Driven TranscriptionCellular and molecular regulation of innate inflammatory responsesNF-κB potentiates caspase independent hydrogen peroxide induced cell deathGenome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulationThe small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activationLiver X Receptors Link Lipid Metabolism and Inflammation.Unexpected cellular players in Rett syndrome pathologyGPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.Oxysterols and their cellular effectors.LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model.PPARalpha: energy combustion, hypolipidemia, inflammation and cancerThe silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivoLoss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemiaNuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance.NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids.Liver x receptor signaling pathways and atherosclerosis.Mechanisms establishing TLR4-responsive activation states of inflammatory response genes.miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 geneCoronin 2A mediates actin-dependent de-repression of inflammatory response genes.The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elementsHistone deacetylases and the nuclear receptor corepressor regulate lytic-latent switch gene 50 in murine gammaherpesvirus 68-infected macrophagesInhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis.Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes.Myelin-derived lipids modulate macrophage activity by liver X receptor activationNuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deteriorationNuclear receptors in neurodegenerative diseases.Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance.Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation.Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila.A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity.
P2860
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P2860
Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
description
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im März 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2009/03/15)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/03/15)
@nl
наукова стаття, опублікована в березні 2009
@uk
مقالة علمية (نشرت في 15-3-2009)
@ar
name
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@ast
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@en
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@nl
type
label
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@ast
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@en
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@nl
prefLabel
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@ast
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@en
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
Cooperative NCoR/SMRT interact ...... nflammatory signaling pathways
@en
P2093
Christopher K Glass
Kristen Jepsen
Michael G Rosenfeld
Wendy Huang
P2860
P304
P3181
P356
10.1101/GAD.1773109
P577
2009-03-01T00:00:00Z