A comprehensive survey of small-molecule binding pockets in proteins
about
How special is the biochemical function of native proteins?Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionKnowledge-based fragment binding predictionEvidence of conformational selection driving the formation of ligand binding sites in protein-protein interfacesPredicting Ligand Binding Sites on Protein Surfaces by 3-Dimensional Probability Density Distributions of Interacting AtomsOn the role of physics and evolution in dictating protein structure and functionEffects of the difference in similarity measures on the comparison of ligand-binding pockets using a reduced vector representation of pockets.Resolving protein structure-function-binding site relationships from a binding site similarity network perspective.Investigating the Importance of the Pocket-estimation Method in Pocket-based Approaches: An Illustration Using Pocket-ligand Classification.On the importance of composite protein multiple ligand interactions in protein pockets.Interactions of macromolecular crowding agents and cosolutes with small-molecule substrates: effect on horseradish peroxidase activity with two different substrates.LIBRA: LIgand Binding site Recognition Application.Comprehensive prediction of drug-protein interactions and side effects for the human proteome.Towards a critical evaluation of an empirical and volume-based solvation function for ligand docking.In silico methods for drug repurposing and pharmacologyPolypharmacology in Drug Development: A Minireview of Current Technologies.Strong Ligand-Protein Interactions Derived from Diffuse Ligand Interactions with Loose Binding Sites.Detecting similar binding pockets to enable systems polypharmacology.Global organization of a binding site network gives insight into evolution and structure-function relationships of proteins.Importance of consensus region of multiple-ligand templates in a virtual screening methodAssessing the similarity of ligand binding conformations with the Contact Mode Score.VB-MK-LMF: fusion of drugs, targets and interactions using variational Bayesian multiple kernel logistic matrix factorization.An integrated structure- and system-based framework to identify new targets of metabolites and known drugs.Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Statistical Profiling of One Promiscuous Protein Binding Site: Illustrated by Urokinase Catalytic Domain.Geometric Detection Algorithms for Cavities on Protein Surfaces in Molecular Graphics: A Survey.Advances in the Development of Shape Similarity Methods and Their Application in Drug Discovery
P2860
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P2860
A comprehensive survey of small-molecule binding pockets in proteins
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A comprehensive survey of small-molecule binding pockets in proteins
@ast
A comprehensive survey of small-molecule binding pockets in proteins
@en
A comprehensive survey of small-molecule binding pockets in proteins
@nl
type
label
A comprehensive survey of small-molecule binding pockets in proteins
@ast
A comprehensive survey of small-molecule binding pockets in proteins
@en
A comprehensive survey of small-molecule binding pockets in proteins
@nl
prefLabel
A comprehensive survey of small-molecule binding pockets in proteins
@ast
A comprehensive survey of small-molecule binding pockets in proteins
@en
A comprehensive survey of small-molecule binding pockets in proteins
@nl
P2860
P3181
P1476
A comprehensive survey of small-molecule binding pockets in proteins
@en
P2093
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1003302
P407
P577
2013-10-01T00:00:00Z