SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
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Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondriaSirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activityEmerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disordersThe Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and ProgressionIntracellular Mono-ADP-Ribosylation in Signaling and DiseaseDysregulated metabolism contributes to oncogenesisSirtuins in hematological aging and malignancyInterplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogrammingSirtuins in Cancer: a Balancing Act between Genome Stability and MetabolismSirtuins, metabolism, and DNA repairLoss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective StudyMitochondria in lung diseaseNuclear DNA damage signalling to mitochondria in ageingSchistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targetsExpression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.Sirtuins: guardians of mammalian healthspan.From Krebs to clinic: glutamine metabolism to cancer therapy.Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association.Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue cultureRole of NAD+ and mitochondrial sirtuins in cardiac and renal diseasesIncreased oxidative phosphorylation in response to acute and chronic DNA damage.Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism.Emerging role of sirtuins on tumorigenesis: possible link between aging and cancerOverexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells.SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK.Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunctionCoactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasisMitochondrial sirtuins and their relationships with metabolic disease and cancer.Sirtuins, aging, and cardiovascular risks.Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients.Tumour-suppressive function of SIRT4 in human colorectal cancerUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4.Sirtuin regulation in aging and injuryWhen Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant.Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cellsMicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4Sirt4: the glutamine gatekeeper.
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P2860
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism
description
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2013
@ast
im April 2013 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2013/04/15)
@sk
vědecký článek publikovaný v roce 2013
@cs
wetenschappelijk artikel (gepubliceerd op 2013/04/15)
@nl
наукова стаття, опублікована у квітні 2013
@uk
مقالة علمية (نشرت في 15-4-2013)
@ar
name
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@ast
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@en
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@nl
type
label
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@ast
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@en
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@nl
prefLabel
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@ast
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@en
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@nl
P2093
P2860
P3181
P1433
P1476
SIRT4 has tumor-suppressive ac ...... chondrial glutamine metabolism
@en
P2093
Alec Kimmelman
Alfredo Csibi
Amanda L Souza
Chu-Xia Deng
Clary B Clish
Cuiling Li
Cuiying Xiao
Gaëlle Laurent
John Blenis
Kerry Pierce
P2860
P304
P3181
P356
10.1016/J.CCR.2013.02.024
P50
P577
2013-04-04T00:00:00Z