Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression
about
Lgr4 protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar parallel fiber-Purkinje cell synapsesTargeted deletion of the murine Lgr4 gene decreases lens epithelial cell resistance to oxidative stress and induces age-related cataract formation.Lgr4 is a key regulator of prostate development and prostate stem cell differentiation.LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects.Stat3 upregulates leucine-rich repeat-containing g protein-coupled receptor 4 expression in osteosarcoma cells.Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein.Closing the loop on the bone-resorbing osteoclast.LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is necessary for prostate cancer metastasis via epithelial-mesenchymal transition.Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae.LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.
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P2860
Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression
description
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 2013
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im Mai 2013 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2013/05/24)
@sk
vědecký článek publikovaný v roce 2013
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wetenschappelijk artikel (gepubliceerd op 2013/05/24)
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наукова стаття, опублікована в травні 2013
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name
Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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type
label
Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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prefLabel
Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
@ast
Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
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P2860
P356
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Lgr4/Gpr48 negatively regulate ...... y by targeting CD14 expression
@en
P2093
Binghe Tan
Dekai Zhang
Honghui Han
Weijia Luo
Xiaoling Lu
Yongxiang Zhao
P2860
P304
15131-15141
P356
10.1074/JBC.M113.455535
P407
P577
2013-04-15T00:00:00Z