Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration
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Potential Role of Selenoenzymes and Antioxidant Metabolism in relation to Autism Etiology and PathologySelenoproteins in nervous system development and functionSynthesis and decoding of selenocysteine and human healthSelenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFαThe Roles of Glutathione Peroxidases during Embryo DevelopmentParadoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsImpaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice.Deletion of selenoprotein M leads to obesity without cognitive deficitsSelenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's DiseaseMutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disabilityCompetition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental DiseaseHow Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia.Deletion of selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning and sensorimotor gatingSelenoproteins: molecular pathways and physiological roles.Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration.Transcriptional activation of antioxidants may compensate for selenoprotein deficiencies in Amblyomma maculatum (Acari: Ixodidae) injected with selK- or selM-dsRNA.Mutations disrupting selenocysteine formation cause progressive cerebello-cerebral atrophy.Selenium, selenoproteins and the thyroid gland: interactions in health and disease.Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia.Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout miceExpression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the RetinaExpression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.Selenoprotein biosynthesis defect causes progressive encephalopathy with elevated lactate.Understanding selenoprotein function and regulation through the use of rodent models.Correlations between maternal and neonatal serum selenium levels in full term neonates with hypoxic ischemic encephalopathy.Different Forms of Selenoprotein M Differentially Affect Aβ Aggregation and ROS GenerationContrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis.Aging decreases antioxidant effects and increases lipid peroxidation in the Apolipoprotein E deficient mouseTargeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degenerationDexamethasone-induced selenoprotein S degradation is required for adipogenesisSex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation.Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite.Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesisProstate epithelium-specific deletion of the selenocysteine tRNA gene Trsp leads to early onset intraepithelial neoplasia.Selenium and selenocysteine: roles in cancer, health, and development.Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans.Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons.
P2860
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P2860
Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration
description
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im März 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/03/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/03/01)
@nl
наукова стаття, опублікована в березні 2010
@uk
مقالة علمية (نشرت في مارس 2010)
@ar
name
Neuronal selenoprotein express ...... seizures and neurodegeneration
@ast
Neuronal selenoprotein express ...... seizures and neurodegeneration
@en
Neuronal selenoprotein express ...... seizures and neurodegeneration
@nl
type
label
Neuronal selenoprotein express ...... seizures and neurodegeneration
@ast
Neuronal selenoprotein express ...... seizures and neurodegeneration
@en
Neuronal selenoprotein express ...... seizures and neurodegeneration
@nl
prefLabel
Neuronal selenoprotein express ...... seizures and neurodegeneration
@ast
Neuronal selenoprotein express ...... seizures and neurodegeneration
@en
Neuronal selenoprotein express ...... seizures and neurodegeneration
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Neuronal selenoprotein express ...... seizures and neurodegeneration
@en
P2093
Bradley A. Carlson
Dietmar Schmitz
Dolph L. Hatfield
Jochen Winterer
Lino Tessarollo
Lutz Schomburg
Stephan Roth
P2860
P304
P3181
P356
10.1096/FJ.09-143974
P407
P50
P577
2010-03-01T00:00:00Z