Targeted disruption of the mouse topoisomerase I gene by camptothecin selection - Wikidata - thesis-toulmin - TriplyDB

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

http://www.wikidata.org/entity/Q28591946

about

Cellular roles of dna topoisomerases: a molecular perspective Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen Topoisomerase I in Human Disease Pathogenesis and Treatments Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy DNA topoisomerase I in the mouse central nervous system: Age and sex dependence A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron Topoisomerase levels determine chemotherapy responsein vitroandin vivo Carrot cells contain two top1 genes having the coding capacity for two distinct DNA topoisomerases I.Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha.Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal site Disruption of a DNA topoisomerase I gene affects morphogenesis in Arabidopsis.Arylstibonic acids: novel inhibitors and activators of human topoisomerase IB MGOUN1 encodes an Arabidopsis type IB DNA topoisomerase required in stem cell regulation and to maintain developmentally regulated gene silencing.Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major TOPOISOMERASE1α Acts through Two Distinct Mechanisms to Regulate Stele and Columella Stem Cell Maintenance.Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown.DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde?Transgene-mediated co-suppression of DNA topoisomerase-1 gene in Caenorhabditis elegans.Induction of homologous recombination following in utero exposure to DNA-damaging agents.Targeting to transcriptionally active loci by the hydrophilic N-terminal domain of Drosophila DNA topoisomerase I.Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress Topoisomerase I is essential in Cryptococcus neoformans: role In pathobiology and as an antifungal target.Topoisomerase 1 inhibition reversibly impairs synaptic function.The C-terminal domain but not the tyrosine 723 of human DNA topoisomerase I active site contributes to kinase activity Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission.Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts.Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.Human DNA topoisomerase I: relaxation, roles, and damage control.Repair of topoisomerase I-mediated DNA damage.Iron chelators with topoisomerase-inhibitory activity and their anticancer applications.Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity DNA Topology and Topoisomerases: Teaching a "Knotty" Subject.Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells.The torsional state of DNA within the chromosome.

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P2860

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

http://www.wikidata.org/entity/Q28591946

description

1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 1996

@ast

im Dezember 1996 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 1996/12/01)

@sk

vědecký článek publikovaný v roce 1996

@cs

wetenschappelijk artikel (gepubliceerd op 1996/12/01)

@nl

наукова стаття, опублікована в грудні 1996

@uk

مقالة علمية (نشرت في ديسمبر 1996)

@ar

name

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@ast

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@en

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@nl

type

label

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@ast

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@en

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@nl

prefLabel

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@ast

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@en

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@nl

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P1433

Molecular and Cellular Biology

P1476

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

@en

P2093

K. D. Kluckman

http://www.w3.org/2001/XMLSchema#string

N. Voulomanos

http://www.w3.org/2001/XMLSchema#string

O. Smithies

http://www.w3.org/2001/XMLSchema#string

S. G. Morham

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene.

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae.

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

Genetic analysis of mutations that compensate for loss of Escherichia coli DNA topoisomerase I

DNA topoisomerase I is essential in Drosophila melanogaster

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

Mouse genes encoding DNA topoisomerase I.

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6804–6809

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scholarly article

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1227072

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P356

10.1128/MCB.16.12.6804

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P407

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12

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P478

16

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1996-12-01T00:00:00Z

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14264607

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P698

8943335

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P921

Topoisomerase (DNA) I

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231683

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