Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
about
The Pafah1b complex interacts with the reelin receptor VLDLRMutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and humanNdel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindleKinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migrationAdipose is a conserved dosage-sensitive antiobesity geneGenes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouseNudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dyneinMechanism of positioning the cell nucleus in vertebrate photoreceptorsThe LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 proteinExploiting microarrays to reveal differential gene expression in the nervous systemDirect association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDEMicrotubule plus-end tracking proteins in neuronal developmentCellullar insights into cerebral cortical development: focusing on the locomotion mode of neuronal migrationSpindle orientation in mammalian cerebral cortical developmentExtra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disordersOf mice and men: molecular genetics of congenital heart diseasePhospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionExtracellular and Intracellular Signaling for Neuronal PolarityNeuronal migration and its disorders affecting the CA3 regionDoublecortin knockout mice show normal hippocampal-dependent memory despite CA3 lamination defectsNuclear motility in glioma cells reveals a cell-line dependent role of various cytoskeletal componentsCross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol.Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillinThe crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal developmentGenetic Basis of Brain MalformationsLIS1 is a microtubule-associated phosphoprotein14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndromeMolecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphomaMutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humansMouse genetic models for prepulse inhibition: an early reviewThe DISC locus in psychiatric illnessLis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells.Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plateLis1 is necessary for normal non-radial migration of inhibitory interneuronsCytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway.Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviourTargeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerizationSynergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization
P2860
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P2860
Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
description
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 1998
@ast
im August 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1998/08/01)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/08/01)
@nl
наукова стаття, опублікована в серпні 1998
@uk
name
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@ast
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@en
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@nl
type
label
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@ast
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@en
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@nl
prefLabel
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@ast
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@en
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@nl
P2093
P3181
P356
P1433
P1476
Graded reduction of Pafah1b1 ( ...... and early embryonic lethality
@en
P2093
A. Wynshaw-Boris
C. J. McBain
D. H. Ledbetter
G. D. Clark
M. J. Gambello
M. W. Fleck
S. Hirotsune
P2888
P304
P3181
P356
10.1038/1221
P407
P577
1998-08-01T00:00:00Z