Focal adhesion kinase is required for blood vessel morphogenesis
about
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradationPyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survivalThe LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcriptionStructural basis for the autoinhibition of focal adhesion kinaseVEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylationInhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.pVHL function is essential for endothelial extracellular matrix deposition.Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesisFocal adhesion kinase: in command and control of cell motilityFocal adhesion kinase and endothelial cell apoptosis.Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.Molecular mediators of angiogenesis.Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantation.Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo.Dermal wound healing is subject to redox controlFocal adhesion kinase regulation of neovascularization.The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formationVEGF-induced vascular permeability is mediated by FAK.In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule traffickingNuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis.Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumorsEndorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.Focal adhesion kinase is a phospho-regulated repressor of Rac and proliferation in human endothelial cells.Requirement of focal adhesion kinase in branching tubulogenesis.pH sensing by FAK-His58 regulates focal adhesion remodelingCell biology of embryonic migration.FERM control of FAK function: implications for cancer therapy.Activation of the integrins alpha 5beta 1 and alpha v beta 3 and focal adhesion kinase (FAK) during arteriogenesis.Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width.Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer.Focal adhesion signaling in heart failureFocal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature.Molecular Pathways: Endothelial Cell FAK-A Target for Cancer Treatment.Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors.Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats.Focal adhesion kinase inhibitors are potent anti-angiogenic agents.FAK-heterozygous mice display enhanced tumour angiogenesis.
P2860
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P2860
Focal adhesion kinase is required for blood vessel morphogenesis
description
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Februar 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/02/21)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/02/21)
@nl
наукова стаття, опублікована в лютому 2003
@uk
مقالة علمية (نشرت في 21-2-2003)
@ar
name
Focal adhesion kinase is required for blood vessel morphogenesis
@ast
Focal adhesion kinase is required for blood vessel morphogenesis
@en
Focal adhesion kinase is required for blood vessel morphogenesis
@nl
type
label
Focal adhesion kinase is required for blood vessel morphogenesis
@ast
Focal adhesion kinase is required for blood vessel morphogenesis
@en
Focal adhesion kinase is required for blood vessel morphogenesis
@nl
prefLabel
Focal adhesion kinase is required for blood vessel morphogenesis
@ast
Focal adhesion kinase is required for blood vessel morphogenesis
@en
Focal adhesion kinase is required for blood vessel morphogenesis
@nl
P2093
P3181
P1433
P1476
Focal adhesion kinase is required for blood vessel morphogenesis
@en
P2093
Branka Kovacic
Caroline H. Damsky
Clark Baumbusch
David G. Gardner
Dusko Ilic
Susan McDonagh
P304
P3181
P356
10.1161/01.RES.0000055016.36679.23
P577
2003-02-21T00:00:00Z