Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts
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Human ATP-binding cassette (ABC) transporter familyThe chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genomeBile salts of vertebrates: structural variation and possible evolutionary significanceLigand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selectionEvolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Modulation of xenobiotic receptors by steroidsMarine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compoundsPXR variants: the impact on drug metabolism and therapeutic responsesChallenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXREvolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid PartnershipCOMPLEX EVOLUTION OF BILE SALTS IN BIRDSDiversity of bile salts in fish and amphibians: evolution of a complex biochemical pathwayEvolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolitesFunctional evolution of the vitamin D and pregnane X receptors.Active nuclear receptors exhibit highly correlated AF-2 domain motionsEvolution of pharmacologic specificity in the pregnane X receptor.Evolutionary history and functional characterization of the amphibian xenosensor CAR.Understanding nuclear receptors using computational methods.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.The importance of discerning shape in molecular pharmacology.The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARRole of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish.Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differentlyFunctional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Evolution of the bile salt nuclear receptor FXR in vertebratesLigand specificity and evolution of liver X receptors.Machine learning methods and docking for predicting human pregnane X receptor activation.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.Intrinsic disorder in nuclear hormone receptors.Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors.Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio)
P2860
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P2860
Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Evolution of the pregnane x re ...... ferences in biliary bile salts
@ast
Evolution of the pregnane x re ...... ferences in biliary bile salts
@en
Evolution of the pregnane x re ...... ferences in biliary bile salts
@nl
type
label
Evolution of the pregnane x re ...... ferences in biliary bile salts
@ast
Evolution of the pregnane x re ...... ferences in biliary bile salts
@en
Evolution of the pregnane x re ...... ferences in biliary bile salts
@nl
prefLabel
Evolution of the pregnane x re ...... ferences in biliary bile salts
@ast
Evolution of the pregnane x re ...... ferences in biliary bile salts
@en
Evolution of the pregnane x re ...... ferences in biliary bile salts
@nl
P2093
P2860
P3181
P356
P1476
Evolution of the pregnane x re ...... ferences in biliary bile salts
@en
P2093
Erin G Schuetz
Kazuto Yasuda
Lee R Hagey
P2860
P304
P3181
P356
10.1210/ME.2004-0427
P407
P577
2005-07-01T00:00:00Z