Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease
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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug DesignStructures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡Characterization of Solanum tuberosum Multicystatin and Its Structural comparison with Other CystatinsSolution Structure of IseA, an Inhibitor Protein of dl-Endopeptidases from Bacillus subtilis , Reveals a Novel Fold with a Characteristic Inhibitory LoopThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsBiochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4Expression, characterization, and cellular localization of knowpains, papain-like cysteine proteases of the Plasmodium knowlesi malaria parasiteThe Ionic and hydrophobic interactions are required for the auto activation of cysteine proteases of Plasmodium falciparumCross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target.Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparumIdentification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenellaCentenary celebrations article: Cysteine proteases of human malaria parasites.Structure-function of falcipains: malarial cysteine proteases.Host pathogen protein interactions predicted by comparative modeling.Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasitesFrom crystal to compound: structure-based antimalarial drug discovery.Molecular recognition in chemical and biological systems.The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis.Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking.2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation.Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-β-bound state.Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. 1. Design, synthesis, biological evaluation and binding model studies.Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association with Artemisinin Resistance.Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases
P2860
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P2860
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structural basis for unique me ...... binding by a malarial protease
@ast
Structural basis for unique me ...... binding by a malarial protease
@en
type
label
Structural basis for unique me ...... binding by a malarial protease
@ast
Structural basis for unique me ...... binding by a malarial protease
@en
prefLabel
Structural basis for unique me ...... binding by a malarial protease
@ast
Structural basis for unique me ...... binding by a malarial protease
@en
P2093
P2860
P50
P356
P1476
Structural basis for unique me ...... binding by a malarial protease
@en
P2093
John R Somoza
Kailash C Pandey
Linda S Brinen
Puran S Sijwali
Robert J Fletterick
Stephanie X Wang
P2860
P304
P356
10.1073/PNAS.0600489103
P407
P577
2006-08-01T00:00:00Z