Adenosine receptors as drug targets--what are the challenges? - Wikidata - thesis-toulmin - TriplyDB

Adenosine receptors as drug targets--what are the challenges?

Adenosine receptors as drug targets--what are the challenges?

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The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment The purinergic neurotransmitter revisited: a single substance or multiple players?Potential for developing purinergic drugs for gastrointestinal diseases HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.The Role of Purine Metabolites as DAMPs in Acute Graft-versus-Host Disease Graft versus host disease: New insights into A2A receptor agonist therapy Ostracising caffeine from the pharmacological arsenal for attention-deficit hyperactivity disorder--was this a correct decision? A literature review N(6)-isopentenyladenosine and analogs activate the NRF2-mediated antioxidant response Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors.Adenosine regulates the proinflammatory signaling function of thrombin in endothelial cells Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC.Caffeine inhibits hypothalamic A1R to excite oxytocin neuron and ameliorate dietary obesity in mice Adenosine receptors and caffeine in retinopathy of prematurity.Extracellular adenosine-mediated modulation of regulatory T cells.Liver alkaline phosphatase: a missing link between choleresis and biliary inflammation.Extracellular nucleotide and nucleoside signaling in vascular and blood disease Big opportunities for small molecules in immuno-oncology.Mechanisms of naturally evolved ethanol resistance in Drosophila melanogaster Caffeinated Alcoholic Beverages - An Emerging Trend in Alcohol Abuse.Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73).In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists.PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity.Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy.Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus ATP as a multi-target danger signal in the brain.Molecular docking screening using agonist-bound GPCR structures: probing the A2A adenosine receptor.I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis.Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity.An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation.The discovery of a selective and potent A2a agonist with extended lung retention.Medicinal chemistry of adenosine, P2Y and P2X receptors.

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Adenosine receptors as drug targets--what are the challenges?

http://www.wikidata.org/entity/Q29346491

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2013 nî lūn-bûn

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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Adenosine receptors as drug targets--what are the challenges?

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Adenosine receptors as drug targets--what are the challenges?

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Adenosine receptors as drug targets--what are the challenges?

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Adenosine receptors as drug targets--what are the challenges?

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Nature Reviews Drug Discovery

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Adenosine receptors as drug targets--what are the challenges?

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Bertil B Fredholm

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Holger K Eltzschig

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Jiang-Fan Chen

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P2860

Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee

Structure of an agonist-bound human A2A adenosine receptor

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart

Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery

Adenosine receptors as therapeutic targets

Adenosine signaling and function in glial cells

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