A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
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Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulatorLoss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB SignalingC9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?RNA metabolism in neurodegenerative disease.Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms.Mouse Models of C9orf72 Hexanucleotide Repeat Expansion in Amyotrophic Lateral Sclerosis/ Frontotemporal DementiaElevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiencyLoss of C9orf72 function leads to autoimmunityRabs, Membrane Dynamics, and Parkinson's Disease.Could Sirtuin Activities Modify ALS Onset and Progression?Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72.Multifaceted role of SMCR8 as autophagy regulator.The Enigmatic Role of C9ORF72 in AutophagyIs amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression.The mammalian ULK1 complex and autophagy initiation.A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration.Current Advances and Limitations in Modeling ALS/FTD in a Dish Using Induced Pluripotent Stem Cells.Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.A Molecular Perspective of Mammalian Autophagosome Biogenesis.High frequency of C9orf72 hexanucleotide repeat expansion in amyotrophic lateral sclerosis patients from two founder populations sharing the same risk haplotype.C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy.Autophagy as a common pathway in amyotrophic lateral sclerosis.Perturbed autophagy and DNA repair converge to promote neurodegeneration in amyotrophic lateral sclerosis and dementia.Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.Patient-Derived iPSCs and iNs-Shedding New Light on the Cellular Etiology of Neurodegenerative Diseases.Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers
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P2860
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
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2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
name
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
@ast
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
@en
type
label
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
@ast
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
@en
prefLabel
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
@ast
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
@en
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
@en
P2093
Chen Liang
Jian-Fu Chen
Ramin Shiekhattar
P2860
P304
P3181
P356
10.1126/SCIADV.1601167
P577
2016-09-02T00:00:00Z