about
The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndromeCamptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53DNA end resection by CtIP and exonuclease 1 prevents genomic instabilityThe MMS22L-TONSL complex mediates recovery from replication stress and homologous recombinationA human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damageCDK targets Sae2 to control DNA-end resection and homologous recombinationTopoisomerase inhibitors unsilence the dormant allele of Ube3a in neuronsHistone H3 lysine 56 acetylation and the response to DNA replication fork damageInhibition of topoisomerase I prevents chromosome breakage at common fragile sitesOptimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKIdentification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transportersImplication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseAtaxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaksATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brainThe Expanding Landscape of Moonlighting Proteins in YeastsTherapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem CellsNanomedicine developments in the treatment of metastatic pancreatic cancer: focus on nanoliposomal irinotecanInhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer TherapyGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsEZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumorsImmunodetection of human topoisomerase I-DNA covalent complexesProgrammed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitorγH2A binds Brc1 to maintain genome integrity during S-phaseAlleviating Cancer Drug Toxicity by Inhibiting a Bacterial EnzymeAnalysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyPharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy.Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesionProgress and problems with the use of suicide genes for targeted cancer therapyThe broken genome: genetic and pharmacologic approaches to breaking DNAProteome half-life dynamics in living human cellsBPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft modelCollaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repairTopoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thalianaA combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian deliveryExploring DNA topoisomerase I ligand space in search of novel anticancer agentsIdentification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigreesChemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cellsIdentification of BC005512 as a DNA damage responsive murine endogenous retrovirus of GLN family involved in cell growth regulationNVX-412, a new oncology drug candidate, induces S-phase arrest and DNA damage in cancer cells in a p53-independent manner
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Topoisomerase I inhibitors: camptothecins and beyond
@ast
Topoisomerase I inhibitors: camptothecins and beyond
@en
type
label
Topoisomerase I inhibitors: camptothecins and beyond
@ast
Topoisomerase I inhibitors: camptothecins and beyond
@en
prefLabel
Topoisomerase I inhibitors: camptothecins and beyond
@ast
Topoisomerase I inhibitors: camptothecins and beyond
@en
P3181
P356
P1476
Topoisomerase I inhibitors: camptothecins and beyond
@en
P2093
P2888
P304
P3181
P356
10.1038/NRC1977
P407
P577
2006-10-01T00:00:00Z
P6179
1028961158