Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice - Wikidata - thesis-toulmin - TriplyDB

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

http://www.wikidata.org/entity/Q29615438

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Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)Chemoprotection by phenolic antioxidants Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Role of Nrf2 in oxidative stress and toxicity Inhibition of activator protein-1, NF-kappa B, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2 Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the Nrf2 pathway NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation Disruption of Nrf2 synergizes with high glucose to cause heightened myocardial oxidative stress and severe cardiomyopathy in diabetic mice Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2 The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway The GI-GPx gene is a target for Nrf2 Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology Does Nrf2 contribute to p53-mediated control of cell survival and death?Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Advances in mechanisms of anti-oxidation The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state Metabolic, autophagic, and mitophagic activities in cancer initiation and progression Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?Role of p62/SQSTM1 in liver physiology and pathogenesis Roles nrf2 plays in myeloid cells and related disorders Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease

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P2860

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

http://www.wikidata.org/entity/Q29615438

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2001 nî lūn-bûn

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2001 թուականի Մարտին հրատարակուած գիտական յօդուած

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2001 թվականի մարտին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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Sensitivity to carcinogenesis ...... cription factor-deficient mice

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Sensitivity to carcinogenesis ...... cription factor-deficient mice

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Sensitivity to carcinogenesis ...... cription factor-deficient mice

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Sensitivity to carcinogenesis ...... cription factor-deficient mice

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Sensitivity to carcinogenesis ...... cription factor-deficient mice

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Proceedings of the National Academy of Sciences of the United States of America

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Sensitivity to carcinogenesis ...... cription factor-deficient mice

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Dolan PM

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Itoh K

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Kensler TW

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Kwak MK

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Ramos-Gomez M

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Talalay P

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Yamamoto M

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P2860

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Nrf2 is essential for protection against acute pulmonary injury in mice

Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione

Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane

Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene

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10.1073/PNAS.051618798

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6

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98

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