Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics - Wikidata - thesis-toulmin - TriplyDB

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

http://www.wikidata.org/entity/Q29615944

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Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1 Transcriptional regulation of BRCA1 expression by a metabolic switch Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1 Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells HIF-1: upstream and downstream of cancer metabolism Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy Blue-Print Autophagy: Potential for Cancer Treatment Clinical significance of T cell metabolic reprogramming in cancer Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles Biogenesis Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications Hypoxic control of metastasis A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance p73: a Positive or Negative Regulator of Angiogenesis, or Both?Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication Progress toward overcoming hypoxia-induced resistance to solid tumor therapy Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date Oxygen levels and the regulation of cell adhesion in the nervous system: a control point for morphogenesis in development, disease and evolution?Is cancer a metabolic disease?Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?Role of hypoxia-inducible factors in breast cancer metastasis HypoxamiRs and cancer: from biology to targeted therapy Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis Hypoxia-mediated regulation of macrophage functions in pathophysiology Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy Hypoxia-inducible factors in physiology and medicine Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells.The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases Structure-Based Design of Covalent Siah Inhibitors The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy Role of Chemotherapy and Mechanisms of Resistance to Chemotherapy in Metastatic Castration-Resistant Prostate Cancer

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

http://www.wikidata.org/entity/Q29615944

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2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Loss of PTEN facilitates HIF-1-mediated gene expression

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10.1038/ONC.2009.441

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