Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification
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A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicingNucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesisRRS1, a conserved essential gene, encodes a novel regulatory protein required for ribosome biogenesis in Saccharomyces cerevisiae.Yeast Pescadillo is required for multiple activities during 60S ribosomal subunit synthesis.Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind S-adenosyl-L-methionine in vitroERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAsDiazaborine treatment of yeast cells inhibits maturation of the 60S ribosomal subunitThe yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleasesU24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNAA small nucleolar RNA requirement for site-specific ribose methylation of rRNA in XenopusRok1p is a putative RNA helicase required for rRNA processingRrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae.Dbp9p, a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis, functionally interacts with Dbp6pA novel complex of membrane proteins required for formation of a spherical nucleus.Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modificationSpb4p, an essential putative RNA helicase, is required for a late step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae.The Saccharomyces cerevisiae TIF6 gene encoding translation initiation factor 6 is required for 60S ribosomal subunit biogenesis.Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing.A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distributionProcessing of 20S pre-rRNA to 18S ribosomal RNA in yeast requires Rrp10p, an essential non-ribosomal cytoplasmic proteinNop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast.Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export.Dbp7p, a putative ATP-dependent RNA helicase from Saccharomyces cerevisiae, is required for 60S ribosomal subunit assembly.Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-rRNA processing predominantly at site A3.Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1.RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase is essential for viability, and a single Leu-to-Pro mutation in a conserved sequence leads to thermosensitivitySaccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits.Yeast Rrp14p is required for ribosomal subunit synthesis and for correct positioning of the mitotic spindle during mitosis.Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57p.Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNAYeast Nop15p is an RNA-binding protein required for pre-rRNA processing and cytokinesisYeast Rrp9p is an evolutionarily conserved U3 snoRNP protein essential for early pre-rRNA processing cleavages and requires box C for its association.Dbp10p, a putative RNA helicase from Saccharomyces cerevisiae, is required for ribosome biogenesis.Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43pDbp6p is an essential putative ATP-dependent RNA helicase required for 60S-ribosomal-subunit assembly in Saccharomyces cerevisiaeNuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p.Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivoFunctional analysis of Rrp7p, an essential yeast protein involved in pre-rRNA processing and ribosome assembly.A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease
P2860
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P2860
Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification
description
1994 nî lūn-bûn
@nan
1994 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Synthetic lethality with fibri ...... NA processing and modification
@ast
Synthetic lethality with fibri ...... NA processing and modification
@en
type
label
Synthetic lethality with fibri ...... NA processing and modification
@ast
Synthetic lethality with fibri ...... NA processing and modification
@en
prefLabel
Synthetic lethality with fibri ...... NA processing and modification
@ast
Synthetic lethality with fibri ...... NA processing and modification
@en
P2093
P2860
P3181
P1433
P1476
Synthetic lethality with fibri ...... NA processing and modification
@en
P2093
P2860
P304
P3181
P356
10.1002/J.1460-2075.1994.TB06612.X
P407
P577
1994-07-01T00:00:00Z