Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
about
Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Genetics and its potential to improve type 1 diabetes care.Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseasesGenome-wide association study of antisocial personality disorder.The MHC locus and genetic susceptibility to autoimmune and infectious diseases.The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ GenotypePredicting diabetes mellitus genes via protein-protein interaction and protein subcellular localization information.Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases.Interactions within the MHC contribute to the genetic architecture of celiac diseaseAssociation of HLA Genotype and Fulminant Type 1 Diabetes in KoreansMajor histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis.Genetic variation in MHC proteins is associated with T cell receptor expression biasesBuilding and Validating a Prediction model for Pediatric Type 1 Diabetes Risk Using Next Generation Targeted Sequencing of Class II HLA Genes.Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank.Association Analysis of the MHC in Lupus Nephritis.Genetics of autoimmune diseases: perspectives from genome-wide association studies.Population-based approaches to genetics of migraine.Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.Immune Intervention and Preservation of Pancreatic Beta Cell Function in Type 1 Diabetes.Sumoylation Modulates the Susceptibility to Type 1 Diabetes.Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis.New insights into the understanding of MHC associations with immune-mediated disorders.Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseasesImmunogenomic approaches to understand the function of immune disease variants.Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles.Fine mapping the MHC region identified four independent variants modifying susceptibility to chronic hepatitis B in Han Chinese.BOLA-DRB3 gene polymorphisms influence bovine leukaemia virus infection levels in Holstein and Holstein × Jersey crossbreed dairy cattle.Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases.MergeReference: A Tool for Merging Reference Panels for HLA ImputationIslet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.The Promise and Practice of Genetics on Diabetes Care: The Fog Rises to Reveal a Field of Genetic Complexity in HNF1B.C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.HLA Class I or Class II and Disease Association: Catch the Difference If You Can.Human leucocyte antigens class II allele and haplotype association with Type 1 Diabetes in Madeira Island (Portugal).Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.HLA variation and disease.Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans.
P2860
Q26767040-91B524A4-258D-4B35-87B5-448EEAFE4B3FQ30252400-B7C0C9BB-49CF-4563-8B34-ACE224EB2176Q30278872-801C7570-0D0C-4339-9E52-4B8D386CCC09Q30489799-83DEF66B-864F-4B0B-AE99-00927243579CQ33608703-01B0221D-29DD-4AAC-A789-969112DF48C7Q33737477-CCEEEA5B-C576-4386-9452-2F49BCACBA18Q36106288-189ADEF9-8EB9-432E-ABEC-4691D782F173Q36247731-38CBCC8B-C771-49A7-9A5C-1585371BA45EQ36304386-A4B7612F-EE3F-4424-A2B7-6343D3B0D0F2Q36547106-49DDF020-3DDF-4E13-AB7F-CF5FA26E5125Q36830253-D5129F89-042D-4AB9-A257-BF8E43392AF1Q37231156-A7F56E9E-BAE5-4A05-91B8-D708DC2673E8Q38650009-1A573D8A-9598-48FF-B4A4-92EA24E9A129Q38651981-3FCB3314-DC21-43BF-8878-6E3016654B85Q38654357-4516B157-AAD5-4934-A9BE-8666BF3F3D93Q38726782-5A7233B9-1B53-402D-BF1C-176541D01758Q38788169-CBEC8518-AD93-469F-AE39-938B41102FD7Q38793657-06D8FA37-3F93-4211-860B-4BCF88A8CDB4Q38828063-4C785425-82D1-40BB-97B0-F66D605275E6Q38961119-C896ACF6-0D3E-4620-94A9-3B1035F39547Q39040207-82F90C5C-830F-4447-B363-795A37B437B2Q39057444-07BDBE6A-2EE0-4227-969B-5D40FBDE3C4EQ39080731-548560EE-9958-4FD3-A4A3-3A16E8E41C13Q39441424-C673FA2C-7773-47F7-864B-49DE82CE1B38Q40089040-CCB35DD1-AB20-46FD-BCC1-AE3CF586380DQ40105875-C16A13BB-5224-4761-AACA-6B40468EE3A1Q40178005-7901FB83-62A0-4FC2-8CD0-9AFF6B2ACA85Q40653044-A7078314-7147-40D7-AD54-2FB4D671A632Q42375266-680F5D65-542D-449A-A972-29A49040DC2DQ45048293-6B6BDAD4-FD0F-46C8-9968-992E861E6B38Q45069924-E9E7B361-9FE1-4A74-B116-DF601BE370B9Q45070793-3DD6E329-66AE-4A6E-9033-D2CA6FBCE6C0Q46237108-24855A42-1CFC-4A1E-BCC1-835C39061F94Q47111038-12BAD6A6-09E1-49D1-B5C6-F80C178A88D6Q48188309-DE6ABD85-099D-4E75-AC1E-4A534550A009Q50042689-76B7A907-5EB6-47E8-AB70-7B2B82C26094Q50060749-05AFAE10-BA04-486C-AC45-4554FCDB71B9Q52679502-1896C110-C67E-408C-9C70-3BB97714D663Q52732932-77C905B7-9799-415E-986E-ECDC75CD6982Q55385543-C7C1B0B1-6BED-4725-944A-EF8A13AF4DC9
P2860
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
description
2015 nî lūn-bûn
@nan
2015 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Additive and interaction effec ...... les drive type 1 diabetes risk
@ast
Additive and interaction effec ...... les drive type 1 diabetes risk
@en
type
label
Additive and interaction effec ...... les drive type 1 diabetes risk
@ast
Additive and interaction effec ...... les drive type 1 diabetes risk
@en
prefLabel
Additive and interaction effec ...... les drive type 1 diabetes risk
@ast
Additive and interaction effec ...... les drive type 1 diabetes risk
@en
P2093
P2860
P50
P356
P1433
P1476
Additive and interaction effec ...... les drive type 1 diabetes risk
@en
P2093
Paul I W de Bakker
Stephen S Rich
Wei-Min Chen
P2860
P2888
P304
P356
10.1038/NG.3353
P407
P577
2015-07-13T00:00:00Z