Discovery and characterization of small molecules that target the GTPase Ral
about
Genetics and biology of pancreatic ductal adenocarcinomaRal GTPases: crucial mediators of exocytosis and tumourigenesisSynthesis of novel Ral inhibitors: An in vitro and in vivo studyDocking Screens for Novel Ligands Conferring New Biology.RalB regulates contractility-driven cancer dissemination upon TGFβ stimulation via the RhoGEF GEF-H1The nuts and bolts of the platelet release reaction.Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia.Drugging the Ral GTPase.Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.TATA boxes in gene transcription and poly (A) tails in mRNA stability: New perspective on the effects of berberine.EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal CancerConstructing and Validating High-Performance MIEC-SVM Models in Virtual Screening for Kinases: A Better Way for Actives Discovery.eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy.Therapeutic Approaches to RAS Mutation.RalA, a GTPase targeted by miR-181a, promotes transformation and progression by activating the Ras-related signaling pathway in chronic myelogenous leukemia.RALB provides critical survival signals downstream of Ras in acute myeloid leukemiaThe RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.Direct Modulation of Small GTPase Activity and Function.Inhibition of Ral GTPases Using a Stapled Peptide Approach.Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies.Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancerRal GTPase and the exocyst regulate autophagy in a tissue-specific manner.Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models.One step closer to targeting RAS.Alpha 7 nicotinic receptor coupling to heterotrimeric G proteins modulates RhoA activation, cytoskeletal motility, and structural growth.Ral signaling pathway in health and cancer.RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer.Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers.Targeting Ras signaling in AML: RALB is a small GTPase with big potential.Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers.Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer.A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc.Understanding the biology of urothelial cancer metastasis.New Approaches to Difficult Drug Targets: The Phosphatase StoryPrediction Methods of Herbal Compounds in Chinese Medicinal Herbs
P2860
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P2860
Discovery and characterization of small molecules that target the GTPase Ral
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Discovery and characterization of small molecules that target the GTPase Ral
@ast
Discovery and characterization of small molecules that target the GTPase Ral
@en
type
label
Discovery and characterization of small molecules that target the GTPase Ral
@ast
Discovery and characterization of small molecules that target the GTPase Ral
@en
prefLabel
Discovery and characterization of small molecules that target the GTPase Ral
@ast
Discovery and characterization of small molecules that target the GTPase Ral
@en
P2093
P2860
P356
P1433
P1476
Discovery and characterization of small molecules that target the GTPase Ral
@en
P2093
Brenton Hoffman
Bryce M Paschal
Charles Owens
Christina L Wysoczynski
Dan Theodorescu
David L Brautigan
David N M Jones
David Ross
Degang Liu
P2860
P2888
P304
P356
10.1038/NATURE13713
P407
P50
P577
2014-09-14T00:00:00Z