CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
about
Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activitiesThe role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implicationsSynthesis of lysine methyltransferase inhibitorsPR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionRegulation of Unperturbed DNA Replication by UbiquitylationGenomic instability in cancer.Sequential replication-coupled destruction at G1/S ensures genome stability.CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencingMultivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome SubstrateA Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.The emerging role of lysine methyltransferase SETD8 in human diseasesDistinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BUbiquitylation, neddylation and the DNA damage responseSET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiationX-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expressionInactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradationDegradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.Efficient parvovirus replication requires CRL4Cdt2-targeted depletion of p21 to prevent its inhibitory interaction with PCNACRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factorThe SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.CRL4Cdt2: master coordinator of cell cycle progression and genome stabilityThe UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression.Thymine DNA glycosylase is a CRL4Cdt2 substrate.The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.A role of tomato UV-damaged DNA binding protein 1 (DDB1) in organ size control via an epigenetic mannerCheckpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Proteome identification of proteins interacting with histone methyltransferase SET8.Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.Defining the replication program through the chromatin landscapeCDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.Genetic variation in a microRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population.Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.
P2860
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P2860
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
CRL4(Cdt2) regulates cell prol ...... g PR-Set7/Set8 for degradation
@ast
CRL4(Cdt2) regulates cell prol ...... g PR-Set7/Set8 for degradation
@en
type
label
CRL4(Cdt2) regulates cell prol ...... g PR-Set7/Set8 for degradation
@ast
CRL4(Cdt2) regulates cell prol ...... g PR-Set7/Set8 for degradation
@en
prefLabel
CRL4(Cdt2) regulates cell prol ...... g PR-Set7/Set8 for degradation
@ast
CRL4(Cdt2) regulates cell prol ...... g PR-Set7/Set8 for degradation
@en
P2860
P50
P1433
P1476
CRL4(Cdt2) regulates cell prol ...... g PR-Set7/Set8 for degradation
@en
P2093
Jonghoon Park
Neerja Karnani
P2860
P356
10.1016/J.MOLCEL.2010.09.014
P577
2010-10-01T00:00:00Z