Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. - Wikidata - thesis-toulmin - TriplyDB

Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

http://www.wikidata.org/entity/Q30437121

about

The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formation The Function of Autophagy in Neurodegenerative Diseases The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy Iron dysregulation in Huntington's disease Huntington's disease: the past, present, and future search for disease modifiers.Autophagy and neurodegeneration Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Autophagy modulation as a potential therapeutic target for diverse diseases Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models.Maintenance of basal levels of autophagy in Huntington's disease mouse models displaying metabolic dysfunction Essential role for autophagy in life span extension Huntingtin functions as a scaffold for selective macroautophagy Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation Potential function for the Huntingtin protein as a scaffold for selective autophagy.Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesi Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice Autophagy impairment induces premature senescence in primary human fibroblasts.Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications Autophagy and ageing: implications for age-related neurodegenerative diseases.Does Huntingtin play a role in selective macroautophagy?Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease Neurodegenerative processes in Huntington's disease.A proteome map of primary cultured rat Schwann cells Mitochondrial Ca(2+) and neurodegeneration Autophagy in axonal and dendritic degeneration.Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy.Integrating metabolism and longevity through insulin and IGF1 signaling.Autophagy and polyglutamine diseases.An in vitro perspective on the molecular mechanisms underlying mutant huntingtin protein toxicity Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis.IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity.Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases.

P2860

Q24307589-4BA0E000-D4D2-4D5B-8003-F3108F4FD628 Q26777018-F0A5432D-81C5-4195-B400-36114DF7B37C Q26823365-1DA1A96E-AB54-465A-99F1-C2368A6954EC Q26829932-A07F4C74-7595-4BA7-89B5-9EEC2F86057A Q26830039-FF13C81E-1F2C-472C-B1E0-9AF87263F287 Q26991692-8BFC1D82-C526-414F-9135-8FFDDA849712 Q26995343-78AC8D1F-594E-432B-841B-EAC030C556E6 Q27010076-12E7AF48-D652-4EDF-A477-58085CF93A48 Q27011387-02E7AFDB-4A8E-46E1-AF9C-2998E71D7852 Q27306025-0FB44615-B6A9-454B-8449-B34C30DF8F70 Q27307913-E7879DF5-16B5-41D8-B763-12120A587223 Q27341821-23A20645-E45F-49B2-BBE2-94C2006FFCFC Q28085050-8E4D19B2-065D-4626-81F4-33D23D3C1D2E Q28118022-3531470C-8866-4666-A18A-86D996C28DE8 Q28273228-96BD1C85-3909-40C6-96A5-FECBCB98D7E9 Q28386493-F52E6B45-6C93-4637-A475-3450E0A012CA Q30301372-5D58AD5D-56FD-4ADE-82DF-616F4C4E740D Q30353131-9331BB5C-E6BC-4756-9EC6-F9FCFF8F0528 Q30355064-D74323CF-FA99-44FD-9698-6ED23989E707 Q30356472-386FA038-3530-4EA3-A5A0-C7607691785F Q30358344-517145E2-3367-4A8C-AD03-37CC22804A3C Q30423904-48088519-3532-469F-A67E-1AE659D3A64C Q30425063-B4AF8FC2-D865-4D74-9CA7-92DB71EF4515 Q33999533-36743B61-3F4E-4897-9FDF-5D58B79E56FF Q34311607-D52A20D8-27DE-4C38-BF22-FC3D7597776A Q34373575-E474AB9F-CB7C-4F4E-8A08-B09FBC0ADDFA Q34618914-CFE9EC7D-D9D7-41BD-B819-0DDF05CD6311 Q34995420-4B7561B1-218B-4DE6-BFFF-54EA090605B4 Q35370058-0C91D77B-4B54-43DD-81DC-E5AFB2BEFD07 Q35572092-355349AA-D320-4038-AEDB-8BFE3D721750 Q35917812-45A745C2-82FC-4891-9894-342D171354F6 Q36095330-1B6A1EF7-695A-4014-A3A6-D6DDC130B76C Q37208557-0A1ACB71-2CC4-4C0B-971F-FDD6C9A16E54 Q37563505-C68614B1-7114-41A0-9309-BD18158A84EB Q37696477-58F6A014-EC05-43C6-A11A-B156DE156E5F Q37935233-7D1901B8-B059-4D4B-9221-590F896FAC12 Q38038981-2F19C225-D510-427D-9BE8-ACC5652C671F Q38223274-9D43FE8B-0CFD-48EC-8FB3-C9987CB73EEF Q38247021-6245D29B-94D7-4712-BF12-7B2A785E584F Q38260329-88FE75AF-5D5D-4D62-87F0-F572EC94907B

P2860

Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

http://www.wikidata.org/entity/Q30437121

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Deletion of the huntingtin pol ...... tophagy and longevity in mice.

@ast

Deletion of the huntingtin pol ...... tophagy and longevity in mice.

@en

type

label

Deletion of the huntingtin pol ...... tophagy and longevity in mice.

@ast

Deletion of the huntingtin pol ...... tophagy and longevity in mice.

@en

prefLabel

Deletion of the huntingtin pol ...... tophagy and longevity in mice.

@ast

Deletion of the huntingtin pol ...... tophagy and longevity in mice.

@en

P1433

Q30437121-99028935-AF11-45A4-9E0C-BEE47E754C6F

P1476

Q30437121-83FA769A-6699-4B1C-8100-919467FA3AB8

P2093

Q30437121-35255BEF-6FA8-41E5-9F92-32EC200FDB76

Q30437121-53E14408-E4F1-42D8-B149-328B651AE702

Q30437121-71E734AE-C3A4-40A0-A900-42BBA55AE89D

Q30437121-CCA4D992-7EDE-44D3-AB60-CDDED8F5C3FC

Q30437121-F33038C0-B0C8-4DDF-BF2F-81F05662782F

P2860

Q30437121-02380DDB-F433-4974-953C-B575579EC267

Q30437121-02BE522D-6648-4FAA-9BB3-24FF33ED4F2D

Q30437121-0A186D73-55B1-4921-95DE-62581B56E845

Q30437121-0F2D2690-82AA-437C-A7A0-257B44BD1D72

Q30437121-1116EE94-20A7-4BEA-9211-BCB4ADA35824

Q30437121-13B55CAD-0077-4443-9992-A9E89BC95D53

Q30437121-13DA62EC-7888-4967-B2DD-C1487579FC36

Q30437121-25C2C103-52E1-4246-A344-3BD88A179110

Q30437121-2D54EE36-659E-4D18-B3B5-4B6CFA228E7E

Q30437121-300025B3-A1A3-46F3-A9A1-F394BB128F7F

P304

Q30437121-26448139-2A1D-44C8-BA5E-AA6A4C94662E

P31

Q30437121-7BC1C695-5EBC-4FFB-A53A-8CA1262A80D0

P356

Q30437121-516F58CF-F977-45DF-81B3-828B06EFFA89

P433

Q30437121-B69D5AA0-EFBF-479F-BD1D-5B8F861C2103

P478

Q30437121-9F9A4AE6-BE3E-4C5B-9107-8CBEF354A47A

P50

Q30437121-7AD0804D-15DB-4AD4-8613-B2A49F57F64E

P577

Q30437121-B8318B76-C42C-491D-A5D6-9A8228A19370

P5875

Q30437121-C5E40EE9-D63D-489D-B512-197A24912484

P698

Q30437121-175D7B8E-86B3-4EAC-8465-142AA5B389B4

P921

Q30437121-B03D6FB5-8439-489E-B48B-2B2404353AD8

P932

Q30437121-27C780B2-74C5-40CC-AD4B-0562485A6022

P356

JOURNAL.PGEN.1000838

P1433

P1476

Deletion of the huntingtin pol ...... utophagy and longevity in mice

@en

P2093

David C Rubinsztein

http://www.w3.org/2001/XMLSchema#string

Erin B D Clabough

http://www.w3.org/2001/XMLSchema#string

Marie Futter

http://www.w3.org/2001/XMLSchema#string

Scott O Zeitlin

http://www.w3.org/2001/XMLSchema#string

Shuqiu Zheng

http://www.w3.org/2001/XMLSchema#string

P2860

Autophagy mediates the mitotic senescence transition

Structural insights into the specific binding of huntingtin proline-rich region with the SH3 and WW domains

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

The hunt for huntingtin function: interaction partners tell many different stories

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Huntingtin interacts with a family of WW domain proteins

P304

e1000838

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PGEN.1000838

http://www.w3.org/2001/XMLSchema#string

P433

2

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P50

P577

2010-02-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

41414692

http://www.w3.org/2001/XMLSchema#string

P698

20140187

http://www.w3.org/2001/XMLSchema#string

P921

P932

2816686

http://www.w3.org/2001/XMLSchema#string