SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. - Wikidata - thesis-toulmin - TriplyDB

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

http://www.wikidata.org/entity/Q30438816

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Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons Modeling psychiatric disorders for developing effective treatments Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders Molecular neurobiological clues to the pathogenesis of bipolar disorder Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) mice Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors.Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides.Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse Genetic aspects of autism spectrum disorders: insights from animal models Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies Epileptic syndromes: From clinic to genetic Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.Adult restoration of Shank3 expression rescues selective autistic-like phenotypes Chronic treatment with mood-stabilizers attenuates abnormal hyperlocomotion of GluA1-subunit deficient mice Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.SHANK proteins: roles at the synapse and in autism spectrum disorder.Expression of SHANK3 in the Temporal Neocortex of Patients with Intractable Temporal Epilepsy and Epilepsy Rat Models.Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding.CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency.Investigation of SHANK3 in schizophrenia.Animal models of bipolar mania: The past, present and future.Modeling mania in preclinical settings: A comprehensive review.Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism Sensory integration in mouse insular cortex reflects GABA circuit maturation Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition.Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit.Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations.Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism.Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling.Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder.Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons.SNP array and FISH analysis of a proband with a 22q13.2- 22qter duplication shed light on the molecular origin of the rearrangement.

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SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

http://www.wikidata.org/entity/Q30438816

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

@ast

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

@en

type

label

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

@ast

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

@en

prefLabel

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

@ast

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

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SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.

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Ankita Patel

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Christian P Schaaf

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Hao Sun

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Hongmei Chen

http://www.w3.org/2001/XMLSchema#string

Hui Lu

http://www.w3.org/2001/XMLSchema#string

Hui-Chen Lu

http://www.w3.org/2001/XMLSchema#string

Hyojin Kang

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Jianrong Tang

http://www.w3.org/2001/XMLSchema#string

Kihoon Han

http://www.w3.org/2001/XMLSchema#string

Peng Yu

http://www.w3.org/2001/XMLSchema#string

P2860

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

Pediatric Bipolar Disorder

Neuroligins and neurexins link synaptic function to cognitive disease

Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

SHANK1 Deletions in Males with Autism Spectrum Disorder

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

Cytoscape: a software environment for integrated models of biomolecular interaction networks

Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

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