Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM
about
Medical immunology: a new journal for a new subspecialty.Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytesA brief history of T cell help to B cellsGlucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching.The structural basis of hyper IgM deficiency - CD40L mutations.Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation.CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated pCyclosporin A inhibits CD40 ligand expression in T lymphocytes.CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.Genome-Edited T Cell Therapies.Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndromeX-linked immunodeficiency with hyper-IgM (XHIM).Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.HOIL-1L interacting protein (HOIP) is essential for CD40 signalingMucosal adjuvanticity of immunostimulatory DNA sequences.Diminished expression of CD40 ligand by activated neonatal T cells.Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM.The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1.Linking class-switch recombination with somatic hypermutation.CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.Organization of the human CD40L gene: implications for molecular defects in X chromosome-linked hyper-IgM syndrome and prenatal diagnosis.Intrinsic defect in B cells of patients with hyper-immunoglobulin M syndrome.Molecular pathology of the X-linked hyper-immunoglobulin M syndrome: detection of wild-type transcripts in a patient with a complex splicing defect of the CD40 ligandSomatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.c-Rel plays a key role in deficient activation of B cells from a non-X-linked hyper-IgM patient.The hyper IgM syndrome--an evolving story.CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection.Application of carrier testing to genetic counseling for X-linked agammaglobulinemiaCD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction.gp39-CD40 interactions are essential for germinal center formation and the development of B cell memoryDisodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells.Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsiveness of X-linked immunodeficient B cells.Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter.Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseasesHyper IgM Syndrome: a Report from the USIDNET Registry
P2860
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P2860
Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM
description
1993 nî lūn-bûn
@nan
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Defective expression of the CD ...... cy with normal or elevated IgM
@ast
Defective expression of the CD ...... cy with normal or elevated IgM
@en
type
label
Defective expression of the CD ...... cy with normal or elevated IgM
@ast
Defective expression of the CD ...... cy with normal or elevated IgM
@en
prefLabel
Defective expression of the CD ...... cy with normal or elevated IgM
@ast
Defective expression of the CD ...... cy with normal or elevated IgM
@en
P2093
P2860
P356
P1476
Defective expression of the CD ...... cy with normal or elevated IgM
@en
P2093
I Stamenkovic
R Fuleihan
P2860
P304
P356
10.1073/PNAS.90.6.2170
P407
P577
1993-03-01T00:00:00Z