The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
about
Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models.Conceptualizing neurodevelopmental disorders through a mechanistic understanding of fragile X syndrome and Williams syndromeAdvances in the Understanding of the Gabaergic Neurobiology of FMR1 Expanded Alleles Leading to Targeted Treatments for Fragile X Spectrum DisorderAltered Neuronal and Circuit Excitability in Fragile X Syndrome.Emerging pharmacologic treatment options for fragile X syndromeLearning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.The contribution of inhibitory interneurons to circuit dysfunction in Fragile X SyndromeGABAergic signaling as therapeutic target for autism spectrum disordersTargeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromesReduced tonic inhibition after stroke promotes motor performance and epileptic seizures.Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and BackReview of targeted treatments in fragile X syndromeSensory processing in autism spectrum disorders and Fragile X syndrome-From the clinic to animal models.From FMRP function to potential therapies for fragile X syndrome.Degraded speech sound processing in a rat model of fragile X syndromeUpdate: studies of prepulse inhibition of startle, with particular relevance to the pathophysiology or treatment of Tourette Syndrome.Pre-clinical models of neurodevelopmental disorders: focus on the cerebellumAuditory processing in fragile x syndrome.The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice.Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse modelModulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives.Modulation of the GABAergic pathway for the treatment of fragile X syndrome.Concise review: Fragile X proteins in stem cell maintenance and differentiationDeletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.Positron Emission Tomography (PET) Quantification of GABAA Receptors in the Brain of Fragile X Patients.A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors.Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research.Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome.Programmed cell death is impaired in the developing brain of FMR1 mutantsPlasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disordersGABAergic dysfunction in pediatric neuro-developmental disorders.GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model.Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome.A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome.Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator.Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.Decreased surface expression of the δ subunit of the GABAA receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome.Altered nocifensive behavior in animal models of autism spectrum disorder: The role of the nicotinic cholinergic system.Increased Training Intensity Induces Proper Membrane Localization of Actin Remodeling Proteins in the Hippocampus Preventing Cognitive Deficits: Implications for Fragile X Syndrome.The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype.
P2860
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P2860
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The GABA(A) receptor agonist T ...... e model of fragile X syndrome.
@ast
The GABA(A) receptor agonist T ...... e model of fragile X syndrome.
@en
type
label
The GABA(A) receptor agonist T ...... e model of fragile X syndrome.
@ast
The GABA(A) receptor agonist T ...... e model of fragile X syndrome.
@en
prefLabel
The GABA(A) receptor agonist T ...... e model of fragile X syndrome.
@ast
The GABA(A) receptor agonist T ...... e model of fragile X syndrome.
@en
P2093
P2860
P356
P1476
The GABA(A) receptor agonist T ...... e model of fragile X syndrome.
@en
P2093
Jose Luis Olmos-Serrano
Joshua G Corbin
Mark P Burns
P2860
P304
P356
10.1159/000332884
P577
2011-11-08T00:00:00Z