PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. - Wikidata - thesis-toulmin - TriplyDB

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

http://www.wikidata.org/entity/Q30480533

about

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5 Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia Genetically-encoded tools for cAMP probing and modulation in living systems Imaging alterations of cardiomyocyte cAMP microdomains in disease The genetically encoded tool set for investigating cAMP: more than the sum of its parts Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations Persistent cAMP-signals triggered by internalized G-protein-coupled receptors "cAMP sponge": a buffer for cyclic adenosine 3', 5'-monophosphate The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization Mechanisms of cyclic AMP compartmentation revealed by computational models.Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2.Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog.Imaging cytoplasmic cAMP in mouse brainstem neurons Transient increase in cyclic AMP localized to macrophage phagosomes.Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits.Conserved expression and functions of PDE4 in rodent and human heart.Soluble adenylyl cyclase in health and disease.PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP Role of membrane microdomains in compartmentation of cAMP signaling.Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.

P2860

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P2860

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

http://www.wikidata.org/entity/Q30480533

description

2006 nî lūn-bûn

@nan

2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

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2006年論文

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2006年论文

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name

PGE(1) stimulation of HEK293 c ...... mentalized phosphodiesterases.

@ast

PGE(1) stimulation of HEK293 c ...... mentalized phosphodiesterases.

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type

label

PGE(1) stimulation of HEK293 c ...... mentalized phosphodiesterases.

@ast

PGE(1) stimulation of HEK293 c ...... mentalized phosphodiesterases.

@en

prefLabel

PGE(1) stimulation of HEK293 c ...... mentalized phosphodiesterases.

@ast

PGE(1) stimulation of HEK293 c ...... mentalized phosphodiesterases.

@en

P1433

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P1433

Journal of Cell Biology

P1476

PGE(1) stimulation of HEK293 c ...... mentalized phosphodiesterases.

@en

P2093

Anke Prinz

http://www.w3.org/2001/XMLSchema#string

Anna Terrin

http://www.w3.org/2001/XMLSchema#string

George Baillie

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Martin J Lynch

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Nicola Elvassore

http://www.w3.org/2001/XMLSchema#string

Vanessa Pertegato

http://www.w3.org/2001/XMLSchema#string

York-Fong Cheung

http://www.w3.org/2001/XMLSchema#string

P2860

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

P304

441-451

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scholarly article

P356

10.1083/JCB.200605050

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P433

3

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P478

175

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P50

Friedrich W. Herberg

Miles D. Houslay

Giulietta Di Benedetto

Manuela Zaccolo

P577

2006-11-01T00:00:00Z

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6709549

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17088426

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2064521

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