The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. - Wikidata - thesis-toulmin - TriplyDB

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

http://www.wikidata.org/entity/Q30490027

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Protein phosphatases and Alzheimer's disease Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's Disease Combotherapy and current concepts as well as future strategies for the treatment of Alzheimer's disease Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem Tau and tauopathies HDAC6 regulates mitochondrial transport in hippocampal neurons Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance.Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surface Phosphoregulation of Tau modulates inhibition of kinesin-1 motility.Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice.Identification of molecular motors in the Woods Hole squid, Loligo pealei: an expressed sequence tag approach.The intersection of amyloid beta and tau at synapses in Alzheimer's disease The role of tau kinases in Alzheimer's disease.Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.Structure and pathology of tau protein in Alzheimer disease.Versatile somatic gene transfer for modeling neurodegenerative diseases.Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases.Adding protein context to the human protein-protein interaction network to reveal meaningful interactions.Sensor potency of the moonlighting enzyme-decorated cytoskeleton: the cytoskeleton as a metabolic sensor Mice with mutation in dynein heavy chain 1 do not share the same tau expression pattern with mice with SOD1-related motor neuron disease Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA.Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics Tau splicing and the intricacies of dementia.Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C).Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.

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P2860

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

http://www.wikidata.org/entity/Q30490027

description

2009 nî lūn-bûn

@nan

2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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name

The amino terminus of tau inhi ...... cations for filament toxicity.

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The amino terminus of tau inhi ...... cations for filament toxicity.

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type

label

The amino terminus of tau inhi ...... cations for filament toxicity.

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The amino terminus of tau inhi ...... cations for filament toxicity.

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The amino terminus of tau inhi ...... cations for filament toxicity.

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The amino terminus of tau inhi ...... cations for filament toxicity.

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Journal of Neuroscience Research

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The amino terminus of tau inhi ...... ications for filament toxicity

@en

P2093

Alan P Kozikowski

http://www.w3.org/2001/XMLSchema#string

Gerardo Morfini

http://www.w3.org/2001/XMLSchema#string

Gustavo Pigino

http://www.w3.org/2001/XMLSchema#string

Lester I Binder

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Nichole E LaPointe

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Scott T Brady

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P2860

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure

Tau and src family tyrosine kinases.

The microtubule binding domain of tau protein.

Can tau filaments be both physiologically beneficial and toxic?

Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid

Multiple-motor based transport and its regulation by Tau.

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440-451

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10.1002/JNR.21850

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2

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87

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18798283

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2739042

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