Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers.
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Synaptic vesicle recycling: steps and principlesDistinct initial SNARE configurations underlying the diversity of exocytosisResident CAPS on dense-core vesicles docks and primes vesicles for fusionOrganization and dynamics of SNARE proteins in the presynaptic membraneRegulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clustersThe role of cholesterol in membrane fusionSyntaxin clusters assemble reversibly at sites of secretory granules in live cells.Experimental approaches for addressing fundamental biological questions in living, functioning cells with single molecule precision.Imaging the post-fusion release and capture of a vesicle membrane proteinIn vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetesDilation of fusion pores by crowding of SNARE proteinsDifferential interaction of tomosyn with syntaxin and SNAP25 depends on domains in the WD40 β-propeller core and determines its inhibitory activity.How could SNARE proteins open a fusion pore?Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.Secretory vesicles are preferentially targeted to areas of low molecular SNARE densityReaDDy--a software for particle-based reaction-diffusion dynamics in crowded cellular environmentsHydrophobic mismatch sorts SNARE proteins into distinct membrane domains.Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site.Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses.Simulation tools for particle-based reaction-diffusion dynamics in continuous space.Coarse-Grained Model of SNARE-Mediated Docking.Dynamical Organization of Syntaxin-1A at the Presynaptic Active ZoneTwo-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cellsNanoscale Landscape of Phosphoinositides Revealed by Specific Pleckstrin Homology (PH) Domains Using Single-molecule Superresolution Imaging in the Plasma Membrane.Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.The mystery of the fusion pore.Imaging the recruitment and loss of proteins and lipids at single sites of calcium-triggered exocytosis.Rapid structural change in synaptosomal-associated protein 25 (SNAP25) precedes the fusion of single vesicles with the plasma membrane in live chromaffin cells.Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes.Stability, folding dynamics, and long-range conformational transition of the synaptic t-SNARE complex.Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle MovementSingle Lipid Molecule Dynamics on Supported Lipid Bilayers with Membrane Curvature.SNARE requirements en route to exocytosis: from many to few.The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.Exocytosis through the LensPI(4,5)P₂-binding effector proteins for vesicle exocytosis.The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions.Munc18-1 protein molecules move between membrane molecular depots distinct from vesicle docking sites.Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions
P2860
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P2860
Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Single secretory granules of l ...... NAP-25) in large copy numbers.
@ast
Single secretory granules of l ...... NAP-25) in large copy numbers.
@en
type
label
Single secretory granules of l ...... NAP-25) in large copy numbers.
@ast
Single secretory granules of l ...... NAP-25) in large copy numbers.
@en
prefLabel
Single secretory granules of l ...... NAP-25) in large copy numbers.
@ast
Single secretory granules of l ...... NAP-25) in large copy numbers.
@en
P2093
P2860
P356
P1476
Single secretory granules of l ...... NAP-25) in large copy numbers.
@en
P2093
M K Knowles
M Midorikawa
Wolfhard Almers
P2860
P304
20810-20815
P356
10.1073/PNAS.1014840107
P407
P577
2010-11-12T00:00:00Z