Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
about
Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndromeDNA damage associated with mitosis and cytokinesis failureCaspase-3 promotes genetic instability and carcinogenesis.Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell linesTranscriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis.Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival.Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents.Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing.Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage.Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide moduleOverlapping and non-overlapping functions of condensins I and II in neural stem cell divisions.Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro.Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice.Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killingThe proliferation rate paradox in antimitotic chemotherapy.MYC Is a Major Determinant of Mitotic Cell Fate.Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics.Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage responseNovel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative ActivityDependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.Linking abnormal mitosis to the acquisition of DNA damageSecreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosisA simplified Bcl-2 network model reveals quantitative determinants of cell-to-cell variation in sensitivity to anti-mitotic chemotherapeutics.Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertensionThe PIDDosome activates p53 in response to supernumerary centrosomes.Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development.The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.Genomic instability and colon carcinogenesis: from the perspective of genes.Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes.Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A.Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy.Complementarity of phosphorylated histones H2AX and H3 quantification in different cell lines for genotoxicity screening.
P2860
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P2860
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Prolonged mitotic arrest trigg ...... n DNA damage and p53 induction
@ast
Prolonged mitotic arrest trigg ...... n DNA damage and p53 induction
@en
type
label
Prolonged mitotic arrest trigg ...... n DNA damage and p53 induction
@ast
Prolonged mitotic arrest trigg ...... n DNA damage and p53 induction
@en
prefLabel
Prolonged mitotic arrest trigg ...... n DNA damage and p53 induction
@ast
Prolonged mitotic arrest trigg ...... n DNA damage and p53 induction
@en
P2860
P356
P1476
Prolonged mitotic arrest trigg ...... n DNA damage and p53 induction
@en
P2093
Galit Lahav
Timothy J Mitchison
P2860
P304
P356
10.1091/MBC.E11-09-0781
P577
2011-12-14T00:00:00Z