Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors
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Chloroquine-enhanced efficacy of cisplatin in the treatment of hypopharyngeal carcinoma in xenograft miceDifferential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagyp62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitorsAutophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype.Tailoring mTOR-based therapy: molecular evidence and clinical challenges.Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitorsAnthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting Akt/mTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition.Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.Regulation of multidrug resistance by microRNAs in anti-cancer therapymTOR pathway in colorectal cancer: an update.A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200†.Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling.Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery.Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor: a phase 1 expansion cohort in patients with relapsed or refractory lyNeurofibromin level directs RAS pathway signaling and mediates sensitivity to targeted agents in malignant peripheral nerve sheath tumors.Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumorTargeting Oncogene-Induced Autophagy: A New Approach in Cancer Therapy?
P2860
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P2860
Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumors
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Targeting the PI3K/mTOR axis, ...... peripheral nerve sheath tumors
@ast
Targeting the PI3K/mTOR axis, ...... peripheral nerve sheath tumors
@en
type
label
Targeting the PI3K/mTOR axis, ...... peripheral nerve sheath tumors
@ast
Targeting the PI3K/mTOR axis, ...... peripheral nerve sheath tumors
@en
prefLabel
Targeting the PI3K/mTOR axis, ...... peripheral nerve sheath tumors
@ast
Targeting the PI3K/mTOR axis, ...... peripheral nerve sheath tumors
@en
P2093
P2860
P1476
Targeting the PI3K/mTOR axis, ...... peripheral nerve sheath tumors
@en
P2093
Aviad Hoffman
Gonzalo Lopez
Jeffery Liu
Kari J Brewer
Keila E Torres
Kristelle Lusby
Markus P Ghadimi
Raphael E Pollock
Roman Belousov
P2860
P304
P356
10.1158/1535-7163.MCT-12-0015
P577
2012-07-30T00:00:00Z