CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis - Wikidata - thesis-toulmin - TriplyDB

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

http://www.wikidata.org/entity/Q30524671

about

Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis Single cell pattern formation and transient cytoskeletal arrays Rho GAPs and GEFs: controling switches in endothelial cell adhesion PP1-Dependent Formin Bnr1 Dephosphorylation and Delocalization from a Cell Division Site Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway.Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.A complex of p190RhoGAP-A and anillin modulates RhoA-GTP and the cytokinetic furrow in human cells.Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.Inhibition of Cdc42 during mitotic exit is required for cytokinesis.RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex Anillin-dependent organization of septin filaments promotes intercellular bridge elongation and Chmp4B targeting to the abscission site A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis Discovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells.CYK-4 regulates Rac, but not Rho, during cytokinesis.MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells.Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesis Rap1-dependent pathways coordinate cytokinesis in Dictyostelium.Cytokinesis in animal cells The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis.Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A Rho GTPases in animal cell cytokinesis: an occupation by the one percent.Microtubules and actin crosstalk in cell migration and division.Controlling the switches: Rho GTPase regulation during animal cell mitosis.TD-60 links RalA GTPase function to the CPC in mitosis.R-loops induce repressive chromatin marks over mammalian gene terminators.Using in vivo biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells.IQGAP1 is a key node within the small GTPase network Stuck in the middle: Rac, adhesion, and cytokinesis.An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3β signaling in breast cancer cells.A GAP that Divides Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers.High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis.FAK inhibitors induce cell multinucleation and dramatically increase pro-tumoral cytokine expression in RAW 264.7 macrophages.Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis.The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.Centralspindlin is required for thorax development during Drosophila metamorphosis.

P2860

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P2860

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

http://www.wikidata.org/entity/Q30524671

description

2012 nî lūn-bûn

@nan

2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

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2012年論文

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2012年论文

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name

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

@ast

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

@en

type

label

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

@ast

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

@en

prefLabel

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

@ast

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

@en

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P1476

CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis

@en

P2093

Dean Hammond

http://www.w3.org/2001/XMLSchema#string

Francis A Barr

http://www.w3.org/2001/XMLSchema#string

Michelle Bates

http://www.w3.org/2001/XMLSchema#string

Ricardo Nunes Bastos

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Xenia Penate

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P2860

Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation

Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity

Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis

Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

An ECT2-centralspindlin complex regulates the localization and function of RhoA

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

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10.1083/JCB.201204107

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198

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230791416

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22945935

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3432774

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