Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs) - Wikidata - thesis-toulmin - TriplyDB

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

http://www.wikidata.org/entity/Q30557755

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Biophysical methods for the characterization of PTEN/lipid bilayer interactions The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors Analytical Aspects of Hydrogen Exchange Mass Spectrometry The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site Resolution of protein structure by mass spectrometry.Genome-scale transcriptional analysis reveals key genes associated with the development of type II diabetes in mice.Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.Peptide and small molecule inhibitors of HECT-type ubiquitin ligases Applications of hydrogen/deuterium exchange MS from 2012 to 2014.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Variation in the Phosphoinositide 3-Kinase Gamma Gene Affects Plasma HDL-Cholesterol without Modification of Metabolic or Inflammatory Markers.Hydrogen Exchange Mass Spectrometry of Proteins at Langmuir Monolayers Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.Crossroads of PI3K and Rac pathways.PI3King the right partner: unique interactions and signaling by p110β.p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration.Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry.Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment.Scaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow.Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase γ Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.Identification of the Rab5 binding site in p110β: assays for PI3Kβ binding to Rab5.The regulatory subunits of PI3Kγ control distinct neutrophil responses.Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas.Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.GPCR Signaling Mediates Tumor Metastasis via PI3Kβ Molecular mechanism for muscarinic M1 receptor-mediated endocytosis of TWIK-related acid-sensitive K+ 1 channels in rat adrenal medullary cells.An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration.Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy.

P2860

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P2860

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

http://www.wikidata.org/entity/Q30557755

description

2013 nî lūn-bûn

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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Molecular determinants of PI3K ...... tein-coupled receptors (GPCRs)

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Molecular determinants of PI3K ...... tein-coupled receptors (GPCRs)

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Molecular determinants of PI3K ...... tein-coupled receptors (GPCRs)

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Molecular determinants of PI3K ...... tein-coupled receptors (GPCRs)

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Molecular determinants of PI3K ...... tein-coupled receptors (GPCRs)

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Molecular determinants of PI3K ...... tein-coupled receptors (GPCRs)

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PNAS.1304801110

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Proceedings of the National Academy of Sciences of the United States of America

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Molecular determinants of PI3K ...... tein-coupled receptors (GPCRs)

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P2093

Aliaksei Shymanets

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Anne R Bresnick

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Bassem D Khalil

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Christian Harteneck

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Jonathan M Backer

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Olga Perisic

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Oscar Vadas

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Widian F Abi Saab

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P2860

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

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10.1073/PNAS.1304801110

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47

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110

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Roger L. Williams

Bernd Nürnberg

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2013-11-04T00:00:00Z

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258282651

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24190998

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G protein-coupled receptor

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