Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.
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CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+.Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.Supersensitive Ras activation in dendrites and spines revealed by two-photon fluorescence lifetime imaging.The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes.Oscillatory ROP GTPase activation leads the oscillatory polarized growth of pollen tubes.Methylation determines fibroblast activation and fibrogenesis in the kidney.Differential Regulation of RasGAPs in Cancer.The Ras GTPase-activating protein Rasal3 supports survival of naive T cells.Strain Differences in Presynaptic Function: PROTEOMICS, ULTRASTRUCTURE, AND PHYSIOLOGY OF HIPPOCAMPAL SYNAPSES IN DBA/2J AND C57Bl/6J MICEEpigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.Calcium signaling in vertebrate embryonic patterning and morphogenesisThe role of promoter hypermethylation in fibroblast activation and fibrogenesis.Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.Calcium signaling in the liverRas activation revisited: role of GEF and GAP systems.The functional contribution of calcium ion flux heterogeneity in T cells.Unravelling the mechanism of dual-specificity GAPs.A Bayesian approach to modelling heterogeneous calcium responses in cell populations.GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.Decoding Ca2+ signals: a question of timing.Manganese interferes with calcium, perturbs ERK signaling, and produces embryos with no skeleton.Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity.Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes
P2860
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P2860
Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations.
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2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2004 թվականի ապրիլին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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name
Identification of a Ras GTPase ...... or-mediated Ca2+ oscillations.
@ast
Identification of a Ras GTPase ...... or-mediated Ca2+ oscillations.
@en
type
label
Identification of a Ras GTPase ...... or-mediated Ca2+ oscillations.
@ast
Identification of a Ras GTPase ...... or-mediated Ca2+ oscillations.
@en
prefLabel
Identification of a Ras GTPase ...... or-mediated Ca2+ oscillations.
@ast
Identification of a Ras GTPase ...... or-mediated Ca2+ oscillations.
@en
P2093
P2860
P356
P1433
P1476
Identification of a Ras GTPase ...... or-mediated Ca2+ oscillations.
@en
P2093
Alan Buckler
Dalila Bouyoucef
Guy A Rutter
Gyles E Cozier
Louise C Davies
Mark R Philips
Maxine J Allen
Peter J Lockyer
Sabine Kupzig
Simon A Walker
P2860
P304
P356
10.1038/SJ.EMBOJ.7600197
P407
P577
2004-04-01T00:00:00Z