Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.
about
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycleDifferential role of RB in response to UV and IR damage.NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosisThe retinoblastoma tumor-suppressor gene, the exception that proves the rulecAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA.Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell deathThe history and future of targeting cyclin-dependent kinases in cancer therapy.p21(CIP1) Controls proliferating cell nuclear antigen level in adult cardiomyocytesBicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways.Dual roles of PARP-1 promote cancer growth and progression.A role for Mediator complex subunit MED13L in Rb/E2F-induced growth arrestRetinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation.RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insultDual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivoOverexpression of non‑SMC condensin I complex subunit G serves as a promising prognostic marker and therapeutic target for hepatocellular carcinoma.Alternol induces an S-phase arrest of melanoma B16F0 cells.Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progressionDefective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice.Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly.RB reversibly inhibits DNA replication via two temporally distinct mechanisms.Distinct mechanisms for regulating the tumor suppressor and antiapoptotic functions of Rb.Cell type-specific responses of human cells to inhibition of replication licensing.Phosphorylation site mutated RB exerts contrasting effects on apoptotic response to different stimuli.Geminin is targeted for repression by the retinoblastoma tumor suppressor pathway through intragenic E2F sites.Modulation of adenylate cyclase signaling in association with MKK3/6 stabilization under combination of SAC and berberine to reduce HepG2 cell survivability.Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
P2860
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P2860
Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Retinoblastoma tumor suppresso ...... rupt PCNA function in S phase.
@ast
Retinoblastoma tumor suppresso ...... rupt PCNA function in S phase.
@en
type
label
Retinoblastoma tumor suppresso ...... rupt PCNA function in S phase.
@ast
Retinoblastoma tumor suppresso ...... rupt PCNA function in S phase.
@en
prefLabel
Retinoblastoma tumor suppresso ...... rupt PCNA function in S phase.
@ast
Retinoblastoma tumor suppresso ...... rupt PCNA function in S phase.
@en
P2093
P2860
P1476
Retinoblastoma tumor suppresso ...... rupt PCNA function in S phase.
@en
P2093
A F Fribourg
E S Knudsen
K E Knudsen
Z Sever-Chroneos
P2860
P304
P356
10.1128/MCB.21.12.4032-4045.2001
P407
P577
2001-06-01T00:00:00Z