Genetic dissection of the Down syndrome critical region.
about
DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeSystematic reanalysis of partial trisomy 21 cases with or without Down syndrome suggests a small region on 21q22.13 as critical to the phenotype.Efficient and rapid generation of large genomic variants in rats and mice using CRISMEREOverexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension.Mouse models of Down syndrome: gene content and consequences.Mouse-based genetic modeling and analysis of Down syndrome.Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models.MeDIP Real-Time qPCR has the Potential for Noninvasive Prenatal Screening of Fetal Trisomy 21.Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits.Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism.Rodent models in Down syndrome research: impact and future opportunities.Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome.Differential Brain, Cognitive and Motor Profiles Associated with Partial Trisomy. Modeling Down Syndrome in Mice.Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors.Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans.Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
P2860
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P2860
Genetic dissection of the Down syndrome critical region.
description
2015 nî lūn-bûn
@nan
2015 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Genetic dissection of the Down syndrome critical region.
@ast
Genetic dissection of the Down syndrome critical region.
@en
type
label
Genetic dissection of the Down syndrome critical region.
@ast
Genetic dissection of the Down syndrome critical region.
@en
prefLabel
Genetic dissection of the Down syndrome critical region.
@ast
Genetic dissection of the Down syndrome critical region.
@en
P2093
P2860
P356
P1476
Genetic dissection of the Down syndrome critical region.
@en
P2093
Alexander M Kleschevnikov
Chunhong Liu
Jennifer Peresie
Pavel V Belichenko
William C Mobley
P2860
P304
P356
10.1093/HMG/DDV364
P577
2015-09-15T00:00:00Z