TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. - Wikidata - thesis-toulmin - TriplyDB

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

http://www.wikidata.org/entity/Q31002474

about

Human single-stranded DNA binding proteins are essential for maintaining genomic stability Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma The RNA Splicing Response to DNA Damage Noncoding RNA control of cellular senescence Telomeres-structure, function, and regulation Single-stranded DNA-binding proteins: multiple domains for multiple functions Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic acid binding topology Genome regulation by long noncoding RNAs.Basic biology and therapeutic implications of lncRNA Telomere elongation chooses TERRA ALTernatives A three-state model for the regulation of telomerase by TERRA and hnRNPA1 Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends Spatiotemporal analysis with a genetically encoded fluorescent RNA probe reveals TERRA function around telomeres.The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response.Telomere protection by TPP1/POT1 requires tethering to TIN2 Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer Telomere Biology-Insights into an Intriguing Phenomenon.Heat shock factor 1 promotes TERRA transcription and telomere protection upon heat stress TRIP6 and LPP, but not Zyxin, are present at a subset of telomeres in human cells.The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.RPA and POT1: friends or foes at telomeres?Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes.Replication protein A unfolds G-quadruplex structures with varying degrees of efficiency.Telomerase efficiently elongates highly transcribing telomeres in human cancer cells.Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas.Quantitative interaction screen of telomeric repeat-containing RNA reveals novel TERRA regulators.Telomere maintenance mechanisms in cancer: clinical implications Telomere profiling: toward glioblastoma personalized medicine.Role of TERRA in the regulation of telomere length.TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Cancer chromosomes going to POT1 Long noncoding RNAs(lncRNAs) and the molecular hallmarks of aging.G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding.

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TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

http://www.wikidata.org/entity/Q31002474

description

2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

@ast

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

@en

type

label

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

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TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

@en

prefLabel

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

@ast

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

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TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

@en

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Alice Tse

http://www.w3.org/2001/XMLSchema#string

Jan Karlseder

http://www.w3.org/2001/XMLSchema#string

Lee Zou

http://www.w3.org/2001/XMLSchema#string

Rachel Litman Flynn

http://www.w3.org/2001/XMLSchema#string

Rekha Rai

http://www.w3.org/2001/XMLSchema#string

Richard C Centore

http://www.w3.org/2001/XMLSchema#string

Roderick J O'Sullivan

http://www.w3.org/2001/XMLSchema#string

Sandy Chang

http://www.w3.org/2001/XMLSchema#string

Zhou Songyang

http://www.w3.org/2001/XMLSchema#string

P2860

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

The POT1-TPP1 telomere complex is a telomerase processivity factor

Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n

Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

In vivo stoichiometry of shelterin components

Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

RPA regulates telomerase action by providing Est1p access to chromosome ends.

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

Pot1, the putative telomere end-binding protein in fission yeast and humans

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532-536

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scholarly article

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10.1038/NATURE09772

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7339

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471

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2011-03-13T00:00:00Z

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50377246

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1005500733

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21399625

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3078637

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