Rationally designed mutations convert de novo amyloid-like fibrils into monomeric beta-sheet proteins
about
Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation.De novo proteins from designed combinatorial librariesLipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in miceSolution structure of a de novo protein from a designed combinatorial libraryIonic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone proteinSequence determinants of protein aggregation: tools to increase protein solubility.Crystal structure of monomeric human -2-microglobulin reveals clues to its amyloidogenic propertiesCrystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domainHydrophobic Surface Burial Is the Major Stability Determinant of a Flat, Single-layer β-SheetStructure and dynamics of de novo proteins from a designed superfamily of 4-helix bundlesComputer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet DesignEdge strand engineering prevents native-like aggregation in Sulfolobus solfataricus acylphosphataseOligomeric interfaces under the lens: geminiShort amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case.Beta edge strands in protein structure prediction and aggregation.Searching for folded proteins in vitro and in silico.A method to predict edge strands in beta-sheets from protein sequencesAmino acid alphabet reduction preserves fold information contained in contact interactions in proteins.Specificity in computational protein designImplications of protein structure instability: from physiological to pathological secondary structure.Frozen in Time: The History of Proteins.Stably folded de novo proteins from a designed combinatorial library.Simulation of pH-dependent edge strand rearrangement in human beta-2 microglobulin.Design of bioactive and structurally well-defined peptides from conformationally restricted libraries.Combinatorial approaches to novel proteins.Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides.Selection and structural analysis of de novo proteins from an alpha3beta3 genetic library.Amyloid-associated nucleic acid hybridisation.The amyloid stretch hypothesis: recruiting proteins toward the dark sideCommon attributes of native-state structures of proteins, disordered proteins, and amyloid.Morphological diversity and polymorphism of self-assembling collagen peptides controlled by length of hydrophobic domainsStructure-based prediction reveals capping motifs that inhibit β-helix aggregation.Tau assembly: the dominant role of PHF6 (VQIVYK) in microtubule binding region repeat R3.Folding without charges.Enhancement of essential amino acid contents in crops by genetic engineering and protein design.Protein aggregation in silico.Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis.Studies on bacterial inclusion bodies.The propensity of the bacterial rodlin protein RdlB to form amyloid fibrils determines its function in Streptomyces coelicolorAggregation gatekeeper and controlled assembly of Trpzip β-hairpins
P2860
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P2860
Rationally designed mutations convert de novo amyloid-like fibrils into monomeric beta-sheet proteins
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Rationally designed mutations ...... monomeric beta-sheet proteins
@ast
Rationally designed mutations ...... monomeric beta-sheet proteins
@en
type
label
Rationally designed mutations ...... monomeric beta-sheet proteins
@ast
Rationally designed mutations ...... monomeric beta-sheet proteins
@en
prefLabel
Rationally designed mutations ...... monomeric beta-sheet proteins
@ast
Rationally designed mutations ...... monomeric beta-sheet proteins
@en
P2860
P356
P1476
Rationally designed mutations ...... monomeric beta-sheet proteins
@en
P2093
Michael H Hecht
Weixun Wang
P2860
P304
P356
10.1073/PNAS.052706199
P407
P577
2002-03-01T00:00:00Z