The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
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The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium bergheiA Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF)Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic PocketCrystal structure of a macrophage migration inhibitory factor from Giardia lambliaMIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrationsA new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor.Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.Ostertagia ostertagi macrophage migration inhibitory factor is present in all developmental stages and may cross-regulate host functions through interaction with the host receptor.MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development.The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).Homotrimeric macrophage migration inhibitory factor (MIF) drives inflammatory responses in the corneal epithelium by promoting caveolin-rich platform assembly in response to infection.Arrest Functions of the MIF Ligand/Receptor Axes in Atherogenesis.Predicted structure of MIF/CD74 and RTL1000/CD74 complexesA computational assessment of the predicted structures of Human Macrophage Migration Inhibitory Factor 1 orthologs in parasites and its affinity to human CD74 receptor.Macrophage Migration Inhibitory Factor (MIF): Biological Activities and Relation with Cancer.Exploring the binding mechanisms of MIF to CXCR2 using theoretical approaches.Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors.Molecular chaperone accumulation as a function of stress evidences adaptation to high hydrostatic pressure in the piezophilic archaeon Thermococcus barophilus.A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation.MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.Comparative analysis of macrophage migration inhibitory factors (MIFs) from the parasitic nematode Onchocerca volvulus and the free-living nematode Caenorhabditis elegans.
P2860
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P2860
The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The conformational flexibility ...... e migration inhibitory factor.
@ast
The conformational flexibility ...... e migration inhibitory factor.
@en
type
label
The conformational flexibility ...... e migration inhibitory factor.
@ast
The conformational flexibility ...... e migration inhibitory factor.
@en
prefLabel
The conformational flexibility ...... e migration inhibitory factor.
@ast
The conformational flexibility ...... e migration inhibitory factor.
@en
P2093
P2860
P50
P356
P1433
P1476
The conformational flexibility ...... e migration inhibitory factor.
@en
P2093
Farah El-Turk
Hajer Ouertatani-Sakouhi
Raghavendran Lakshmi Narayanan
Ursula Rothlisberger
P2860
P304
10740-10756
P356
10.1021/BI800603X
P407
P577
2008-09-17T00:00:00Z